PMID: 15240742Jul 9, 2004Paper

Peritoneal exudate cells treated with calcitonin gene-related peptide suppress murine experimental autoimmune uveoretinitis via IL-10

The Journal of Immunology : Official Journal of the American Association of Immunologists
T KezukaM Usui

Abstract

Immunization with retinal Ag induces experimental autoimmune uveoretinitis (EAU) in mice. We investigated the suppression of murine EAU by peritoneal exudate cells (PEC) cultured with calcitonin gene-related peptide (CGRP). PEC derived from mice were treated with CGRP and residues 1-20 of human interphotoreceptor retinoid-binding protein (hIRBP 1-20). The hIRBP 1-20-immunized mice were injected i.v. with PEC treated with CGRP and hIRBP 1-20. After immunization, Ag-specific delayed hypersensitivity (DH) was measured and EAU was assessed histopathologically. Both EAU- and Ag-specific DH were suppressed by injection of PEC treated with CGRP (100 ng/ml) and hIRBP 1-20. However, hIRBP 1-20-mediated EAU was not suppressed by injection of PEC treated with CGRP and BSA. Both EAU- and Ag-specific DH were not suppressed by injection of PEC treated with CGRP and hIRBP 1-20 into splenectomized mice. In mice adoptively transferred spleen cells from hIRBP 1-20-immunized mice, EAU was also suppressed by injection of CGRP-treated PEC. EAU was markedly inhibited in hIRBP 1-20-immunized mice adoptively transferred T cells obtained from mice injected with hIRBP 1-20-pulsed, CGRP-treated PEC. Furthermore, EAU- and Ag-specific DH were not suppresse...Continue Reading

References

Jan 1, 1990·Critical Reviews in Clinical Laboratory Sciences·M ZaidiL H Breimer
Jan 1, 1990·Current Eye Research·J W Streilein, S W Cousins
Jun 1, 1990·Journal of Autoimmunity·C C ChanR B Nussenblatt
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·F A TschoppJ A Fischer
May 1, 1981·The Journal of Experimental Medicine·J W Streilein, J Y Niederkorn
Jul 1, 1996·The Journal of Experimental Medicine·N J DavidsonD M Rennick
Feb 1, 1997·Human Immunology·J W StreileinA W Taylor
Jul 1, 1997·The Journal of Investigative Dermatology·H Niizeki, J W Streilein
Jul 25, 1998·International Immunology·L V RizzoR R Caspi
Dec 20, 2000·The Journal of Investigative Dermatology·T Kitazawa, J W Streilein
May 27, 2003·Investigative Ophthalmology & Visual Science·Andrew W Taylor, David G Yee

❮ Previous
Next ❯

Citations

Apr 11, 2008·Journal of the American Society of Nephrology : JASN·Roland VeelkenGisa Tiegs
Apr 16, 2014·Nature Reviews. Nephrology·Roland Veelken, Roland E Schmieder
May 17, 2007·International Archives of Allergy and Immunology·Atsuki FukushimaHisayuki Ueno
Jul 15, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tilmann DittingRoland Veelken
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mizuki KitamuraKazunori Onoé
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marta A ToscanoGabriel A Rabinovich
Apr 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yoko OkunukiKip M Connor
Jun 8, 2021·Frontiers in Immunology·Yoko OkunukiKip M Connor

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.