Peritoneal fluid and serum levels of hepatocyte growth factor may predict the activity of endometriosis

Acta Obstetricia Et Gynecologica Scandinavica
Khaleque Newaz KhanTadayuki Ishimaru

Abstract

The suitable parameter in PF as well as in serum that may predict the activity of endometriosis is not well described. Therefore, we tried to examine the peritoneal fluid (PF) and serum concentrations of hepatocyte growth factor (HGF) in different revised American Society of Reproductive Medicine (r-ASRM) staging and morphologic appearances of endometriosis in an attempt to determine whether HGF can be clinically useful to predict the activity of pelvic endometriosis. Peritoneal fluid was collected from 137 women with endometriosis and 57 women without endometriosis during laparoscopy and blood sampling was collected from 37 women with endometriosis and 21 women without endometriosis before laparoscopy. The concentration of HGF in PF and serum was measured by enzyme-linked immunosorbent assay. The ability of isolated macrophages and stroma to secrete HGF in response to lipopolysaccharide (LPS) was evaluated. A significantly increased concentration of HGF in PF was found in women with endometriosis (1451.75 +/- 90.7 pg/mL) than that in non-endometriosis (1120.5 +/- 77.3 pg/mL, p < 0.01) without any remarkable difference in HGF levels between women with stage I-/II endometriosis and stage III-/IV endometriosis. When we distribute...Continue Reading

Citations

Jul 4, 2008·Human Reproduction·Khaleque Newaz KhanHideaki Masuzaki
May 14, 2010·Human Reproduction Update·K E MayC M Becker
Nov 12, 2013·Archives of Gynecology and Obstetrics·Nilofar KhoshdelRadEbrahim Mirzajani
Aug 31, 2011·Revista da Associação Médica Brasileira·Patrick BellelisMaurício Simões Abrão
Feb 25, 2009·American Journal of Reproductive Immunology : AJRI·Khaleque Newaz KhanHideaki Masuzaki
Jun 15, 2013·Obstetrics and Gynecology International·Ana Luiza L RochaRobert N Taylor
Aug 5, 2015·BioMed Research International·Amelie FassbenderLinda Giudice
Feb 25, 2014·Medical Hypotheses·K ToorW G Foster
Feb 24, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Khaleque N KhanHideaki Masuzaki
Aug 20, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Gülen YerlikayaHeinrich Husslein
May 2, 2016·The Cochrane Database of Systematic Reviews·Vicki NisenblatM Louise Hull
Jan 24, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hiroshi KobayashiHidekazu Oi
May 18, 2019·American Journal of Reproductive Immunology : AJRI·Young Sik ChoiSung Hoon Kim
Mar 10, 2007·Human Reproduction Update·Matthias W Laschke, Michael D Menger
Jun 10, 2021·International Journal of Women's Health·Lyudmila M MikhalevaMikhail Y Sinelnikov
Jul 13, 2007·Current Opinion in Obstetrics & Gynecology
Sep 16, 2021·American Journal of Reproductive Immunology : AJRI·Khaleque N KhanJo Kitawaki

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