Peritoneal fluid levels of immunoreactive corticotropin-releasing factor (CRF) and CRF-binding protein (CRF-BP) in healthy and endometriosic women

Journal of Endocrinological Investigation
P FlorioF Petraglia

Abstract

Corticotropin-releasing factor (CRF) is a 41-amino acid neurohormone involved in the neuroendocrine response to stress, also playing a role in cell-mediated immune functions and in inflammation. In the light of recent evidence showing an association between endometriosis and altered cellular immunity factors, the present study investigates immunoreactive (ir) CRF in the peritoneal fluid of healthy women, and in patients with pelvic adhesions and endometriosis. In addition, peritoneal fluid concentrations of CRF-binding protein (CRF-BP), a 37-kDA protein of 322 amino acids able to modulate central and peripheral CRF functions, were evaluated. Peritoneal fluid samples (n = 35) were collected from healthy women (n = 12), from patients with intrapelvic adhesions (n = 8), and from women with endometriosis (n = 15). In the control group a specimen of blood was collected. Peritoneal fluid and plasma CRF levels were measured by a two-site immunoradiometric assay (IRMA), and CRF-BP levels were measured by a specific radioimmunoassay (RIA). CRF and CRF-BP levels in peritoneal fluid were lower than plasma values, and independent of the phase of the menstrual cycle: in particular, in healthy women there was no significant difference betwee...Continue Reading

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Citations

Jul 12, 2007·Seminars in Immunopathology·Nadja TariverdianPetra C Arck
Apr 9, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Huayuan ZhuShengnan Li
Nov 10, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Nadja TariverdianPetra C Arck
Feb 24, 2016·Journal of Reproductive Biology and Health·Maria QuiñonesIdhaliz Flores
Nov 16, 2017·Reproductive Sciences·Annelyn Torres-ReverónCaroline B Appleyard
Oct 21, 2004·American Journal of Reproductive Immunology : AJRI·Duraisamy KempurajTheoharis C Theoharides
Apr 2, 1999·Acta Paediatrica. Supplement·A GrütersT Gudermann
Oct 26, 2012·Journal of Psychosomatic Obstetrics and Gynaecology·Karina Friggi Sebe PetrelluzziRegina Celia Spadari
Jun 3, 2000·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M SchmidtA E Schindler

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