Peritoneal interleukin-10 increases with decrease in activated CD4+ T lymphocytes in women with endometriosis

Human Reproduction
H N HoY S Yang

Abstract

This study was performed to determine whether peritoneal T cells are suppressed in the CD4+ or CD8+ T cell subpopulation and whether they are Th1 or Th2 predominant in women with endometriosis. Immune cells in the peritoneal fluid (PF) were obtained from women undergoing laparoscopy for endometriosis or tubal ligation. Three-colour flow cytometry was utilized for immunophenotyping of peritoneal fluid mononuclear cells (PFMC). Concentrations of interleukin (IL)-4, IL-5 and interferon-gamma (IFN-gamma) produced by PFMC with and without mitogen stimulation and concentrations of IL-10 and IL-12 were measured in PF. The peritoneal T lymphocytes were predominantly of the Th1 type that produced much more IFN-gamma but less IL-4 or IL-5 in women with or without endometriosis. The decrease in peritoneal lymphocytes was significant in the HLA-DR+ CD4+ CD3+ subpopulation and the concentrations of peritoneal IL-10 and IL-12 were significantly elevated in women with early stage endometriosis. There was impaired IL-5 production by PFMC after phytohaemagglutinin stimulation in women with advanced stage endometriosis. We concluded that the activated peritoneal CD4+ Th1 cells from the women with endometriosis were decreased in number. The suppr...Continue Reading

Citations

Jan 22, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mohamed A Bedaiwy, Tommaso Falcone
Jul 5, 2001·Fertility and Sterility·T HaradaN Terakawa
Jul 10, 2003·Fertility and Sterility·Danièle GagnéDiane Gosselin
Apr 20, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D VinatierP Dufour
Nov 18, 1998·Current Opinion in Obstetrics & Gynecology·D P Braun, W P Dmowski
Aug 19, 1999·Clinical Obstetrics and Gynecology·C A Witz
Dec 31, 1997·American Journal of Reproductive Immunology : AJRI·H N HoY S Yang
Sep 9, 2009·Reproductive Biology and Endocrinology : RB&E·Hongbo ZhaoYuchun Pan
Mar 9, 2002·American Journal of Reproductive Immunology : AJRI·Jo KitawakiHideo Honjo
Feb 19, 2016·The Journal of Obstetrics and Gynaecology Research·Peng ChenYan-Ming Liang
Sep 22, 2015·American Journal of Reproductive Immunology : AJRI·Masashi TakamuraYutaka Osuga
Apr 21, 2009·Journal of Reproductive Immunology·N TariverdianP C Arck
Oct 22, 2008·Fertility and Sterility·Suh-Hang Hank JuoEing-Mei Tsai
Jul 12, 2003·American Journal of Reproductive Immunology : AJRI·Ming-Yih Wu, Hong-Nerng Ho
Feb 3, 2006·American Journal of Reproductive Immunology : AJRI·Jehn-Hsiahn YangHong-Nerng Ho
Jun 30, 2010·American Journal of Reproductive Immunology : AJRI·Yutaka OsugaYuji Taketani
Jul 14, 2010·American Journal of Reproductive Immunology : AJRI·Mads RiiskjaerChristina Kruse
May 26, 2004·Best Practice & Research. Clinical Obstetrics & Gynaecology·W Paul Dmowski, Donald P Braun
Aug 8, 2015·BioMed Research International·Soo Hyun AhnChandrakant Tayade
Apr 29, 2015·PloS One·Mariela Andrea BilotasRosa Inés Barañao
May 12, 2006·Biology of Reproduction·Belgin SelamAydin Arici
Oct 24, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francesca MiniciRosanna Apa
Oct 4, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Hui-Li YangMing-Qing Li
May 9, 2006·Gynecologic and Obstetric Investigation·Admir AgicDaniela Hornung
Jul 12, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rachel ForsterErin Greaves
Jul 17, 2004·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A GallinelliA Volpe
Oct 16, 2016·Oncotarget·Jessica E MillerChandrakant Tayade
May 16, 2020·Immunological Investigations·Paula Carolina Arvelos CrispimRosekeila Simões Nomelini
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Belgin SelamAydin Arici

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.