Peritoneal Keratin Granulomatosis Associated with Endometrioid Adenocarcinoma of the Uterine Corpus in a Woman with Polycystic Ovaries: A Potential Pitfall-A Case Report and Review of the Literature

Case Reports in Obstetrics and Gynecology
Helen J TrihiaDimitrios C Papatheodorou

Abstract

Peritoneal keratin granulomatosis is a rare condition included under granulomatous lesions of the peritoneum. It can be secondary to neoplasms of the female genital tract and can mimic carcinomatosis intraoperatively. A case of a 40-year-old woman with a history of polycystic ovaries and a chief complaint of vaginal bleeding is presented. She was diagnosed with endometrioid adenocarcinoma with squamous differentiation in endometrial curettings. Intraoperatively, many peritoneal nodules were found, interpreted as peritoneal carcinomatosis. The woman underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy, omentectomy, bilateral pelvic lymphadenectomy, and appendicectomy. Multiple biopsies were taken, as well as peritoneal washings. Microscopic examination revealed multiple keratin granulomas on the serosal surface of the ovaries, fallopian tubes, appendix, and omentum. Lymph node metastasis was not found. Peritoneal keratin granulomas (PKGs) have been reported in cases of endometrioid adenocarcinoma with squamous differentiation of the uterine corpus, ovary, and atypical adenomyoma. It should be noted that the prognosis of cases of peritoneal keratin granulomas without viable tumor cells is favourable and t...Continue Reading

References

Oct 1, 1984·Southern Medical Journal·W D WilliamsA M Rywlin
Jun 1, 1995·American Journal of Clinical Pathology·P B Clement
Jul 1, 1961·American Journal of Obstetrics and Gynecology·M MONTESG L HAIDAK
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T I WuC H Lai
Jul 25, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C van der Horst, A J Evans
Nov 26, 2010·Case Reports in Gastroenterology·Kalpalata TripathySitaram Mahapatra
Oct 5, 2011·Cytopathology : Official Journal of the British Society for Clinical Cytology·F Rivasi, A Palicelli

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