Peritoneal metastasis from pancreatic cancer treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC)

Clinical & Experimental Metastasis
M GraversenM B Mortensen

Abstract

Patients with peritoneal metastasis (PM) from pancreatic cancer have a short life expectancy. Systemic combination chemotherapy leads to a median overall survival of 7-8 months. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is a treatment alternative, where studies in patients with PM from ovarian, gastric and colorectal cancer show a high safety profile and interesting results. This case study report data on the PIPAC treatment in patients with PM from pancreatic cancer. In a standard laparoscopy, chemotherapeutics (cisplatin and doxorubicin) are nebulized within the peritoneal cavity. After 30 min, the chemotherapeutics are evacuated through a closed system. The PIPAC procedure is repeated every 4-6 weeks. Five patients with PM from pancreatic cancer were treated with a total of 16 PIPAC procedures. All patients received >1 PIPAC and were eligible for evaluation of histological regression. Four patients demonstrated histological regression, and one patient had stable disease. Three patients are still alive, and the median overall survival is 14 months (range 10-20) since the diagnosis of PM. The histological regression and survival figures in this pilot study suggest activity of PIPAC with low-dose cisplatin and do...Continue Reading

References

Apr 18, 2001·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·T A SohnK D Lillemoe
Aug 16, 2001·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M OmanL O Hafström
Feb 5, 2005·American Journal of Physiology. Renal Physiology·Michael F Flessner
Sep 6, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Michael G HousePeter J Allen
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
May 15, 2012·Surgical Endoscopy·Wiebke SolaßMarc A Reymond
Aug 23, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J K BjerregaardP Pfeiffer
Feb 5, 2013·Annals of Surgical Oncology·Ana BlancoMarc A Reymond
Mar 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayF Bray
Jun 15, 2013·Annals of Surgical Oncology·Wiebke SolassMarc A Reymond
Feb 24, 2015·Gynecologic Oncology·Clemens B TempferMarc-André Reymond
Sep 25, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Cedric DemtröderMarc-André Reymond
Oct 30, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Giorgi NadiradzeMarc-André Reymond
Dec 26, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·V H CouplandH Møller
Jan 16, 2016·Acta Oncologica·Jon Kroll BjerregaardUNKNOWN Academy of Geriatric Cancer Research (AgeCare)
Feb 6, 2016·Surgery·Alexander P StarkO Joe Hines
Dec 1, 2016·Pleura and Peritoneum·Martin GraversenMichael B Mortensen

❮ Previous
Next ❯

Citations

Aug 12, 2020·Cancer Metastasis Reviews·Leela Rani AvulaChristine Alewine
Jun 9, 2017·Clinical & Experimental Metastasis·Jonathan P Sleeman
Aug 1, 2018·Clinical & Experimental Metastasis·Philipp HorvathMarc André Reymond
May 14, 2019·Minerva medica·Andrea Di GiorgioStefano Rotolo
May 23, 2018·World Journal of Gastroenterology : WJG·Maciej NowackiWojciech Zegarski
Jul 4, 2019·The Lancet Oncology·Mohammad AlyamiVahan Kepenekian
Mar 1, 2021·The British Journal of Surgery·T YadavS Irrinki

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy
pancreatectomy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.