Perivascular adipose tissue and coronary atherosclerosis

Heart
Jennifer MancioCharalambos Antoniades

Abstract

Adipose tissue (AT) is no longer viewed as a passive, energy-storing depot, and a growing body of evidence supports the concept that both quantitative and qualitative aspects of AT are critical in determining an individual's cardiometabolic risk profile. Among all AT sites, perivascular AT (PVAT) has emerged as a depot with a distinctive biological significance in cardiovascular disease given its close anatomical proximity to the vasculature. Recent studies have suggested the presence of complex, bidirectional paracrine and vasocrine signalling pathways between the vascular wall and its PVAT, with far-reaching implications in cardiovascular diagnostics and therapeutics. In this review, we first discuss the biological role of PVAT in both cardiovascular health and disease, highlighting its dual pro-atherogenic and anti-atherogenic roles, as well as potential therapeutic targets in cardiovascular disease. We then review current evidence and promising new modalities on the non-invasive imaging of epicardial AT and PVAT. Specifically, we present how our expanding knowledge on the bidirectional interplay between the vascular wall and its PVAT can be translated into novel clinical diagnostics tools to assess coronary inflammation. To...Continue Reading

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Citations

May 28, 2020·Antioxidants & Redox Signaling·Henry W West, Charalambos Antoniades
Jun 14, 2019·Obesity Surgery·Gian Franco AdamiRenzo Cordera
Jul 31, 2019·International Journal of Molecular Sciences·Mohammed El HafidiRoxana Carbó
Sep 13, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Evangelos K OikonomouCharalambos Antoniades
Jan 4, 2020·Clinical Science·Samah AhmadiehNeal L Weintraub
Jun 11, 2020·Therapeutic Advances in Endocrinology and Metabolism·Regitse Højgaard ChristensenPeter Godsk Jørgensen
Oct 31, 2020·Endocrine Reviews·William B Horton, Eugene J Barrett
Mar 12, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Anton G KutikhinGuido Krenning
Apr 4, 2021·International Journal of Molecular Sciences·Michal Kowara, Agnieszka Cudnoch-Jedrzejewska
Aug 8, 2021·Journal of Clinical Medicine·Gregor S ZimmermannAlexander Becker
Jul 24, 2021·British Journal of Pharmacology·Christos P Kotanidis, Charalambos Antoniades
Dec 11, 2021·Journal of the American Heart Association·Kuo-Tzu SungChung-Lieh Hung
Aug 10, 2021·Cardiovascular & Hematological Agents in Medicinal Chemistry·Mauro GittoGiulio G Stefanini

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