Perivascular and Quadrant Nerve Fiber Layer Thickness and Its Relationship with Oxygen Saturation

Current Eye Research
Ashwin MohanRajesh S Kumar

Abstract

To study whether there exists a relationship between retinal nerve fiber layer thickness and oxygen saturation and to identify whether perivascular thickness (pRNFL) or quadrant thickness (qRNFL) has a stronger correlation. Patients without any detectable ocular abnormality on complete ophthalmic evaluation underwent non-invasive photo-spectrometric retinal oximetry on the Oxymap T1 retinal oximeter (Oxymap hf, Reykjavik, Iceland) and spectral-domain optical coherence tomography to determine if the pRNFL (Spectralis, Heidelberg, Germany) and the qRNFL (RtVue, Optovue) correlated with the measured light intensities and the calculated retinal oxygen saturations. 30 eyes of 30 patients (120 arterioles, 120 venules) were included in the study. The mean arteriolar saturations (%) were temporal: 84.5 (95% CI 82.7-86.3) and nasal: 93.5 (95% CI 91.0-95.8); venous saturations were temporal: 54.4 (95% CI 52.9-55.9) and nasal: 59.9 (95% CI 58.3-61.4). The mean pRNFL thickness (µm) around arterioles was temporal: 153.1 (95% CI 146-159) and nasal: 109.4 (95% CI 103-115); around venules it was temporal: 147.4 (95% CI 140-154) and nasal: 101.2 (95% CI 95-107). The oxygen saturations correlated significantly with pRNFL (arteriolar r = -0.514; ...Continue Reading

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Citations

Jul 21, 2016·PloS One·Yuki NakanoAkitaka Tsujikawa
Nov 4, 2016·Acta Ophthalmologica·Xue LiuLiang Xu
Mar 8, 2019·Acta Ophthalmologica·Ashwin MohanTos T J M Berendschot
May 19, 2021·Translational Vision Science & Technology·Anupam K GargDaniel L Chao

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