Perivascular cells along venules upregulate NG2 expression during microvascular remodeling

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Walter L MurfeeThomas C Skalak

Abstract

Recently the authors have shown that neuron-glial antigen 2 (NG2) is expressed by perivascular cells along arterioles and capillaries, but not along venules in quiescent rat mesenteric microvascular networks. To investigate how the spatial distribution of this proteoglycan changes during microvascular remodeling, the objective of this study was to characterize the expression of NG2 in adult rat mesenteric microvascular networks undergoing active remodeling. The distribution of NG2 expression was evaluated in adult rat mesenteric microvascular networks. Tissues were harvested from 250 g, female, Sprague-Dawley rats at 1, 3, and 5 days poststimulation and double immunolabeled for NG2 and CD31 (endothelial cell marker). After 1 day, NG2 expression was observed along 27 +/- 11% of network draining venules (14-55 microm) and after 3 days, 59 +/- 10% of draining venules (13-59 microm) stained positive for the proteoglycan. By 5 days poststimulation, the percentage of network draining venules (18-59 microm) staining positive for NG2 returned to 18 +/- 7%, indicating a downregulation of the proteoglycan toward quiescent levels along larger-sized venules. The results suggest that NG2 proteoglycan expression is transiently upregulated al...Continue Reading

References

Dec 1, 1992·Cell and Tissue Research·V NehlsD Drenckhahn
Dec 1, 1990·The Journal of Cell Biology·W B StallcupP Healy
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·K NorrbyJ Sörbo
Sep 7, 2001·Developmental Biology·K Othman-HassanJ Wilting
Oct 23, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·U OzerdemW B Stallcup
Oct 26, 2001·Mechanisms of Development·Y HerzogG Neufeld
Dec 26, 2001·Microvascular Research·Ugur OzerdemWilliam B Stallcup
Sep 5, 2002·Nature Reviews. Genetics·Nathan D Lawson, Brant M Weinstein
Jan 22, 2003·Microvascular Research·Ana M Ponce, Richard J Price
Jul 29, 2003·Cell and Tissue Research·Holger Gerhardt, Christer Betsholtz
Dec 19, 2003·Development·Ferdinand le NobleAnne Eichmann
Jul 28, 2004·Investigative Ophthalmology & Visual Science·Suzanne Hughes, Tailoi Chan-Ling
Dec 21, 2004·Angiogenesis·Ugur Ozerdem, William B Stallcup
Jan 29, 2005·Annals of Biomedical Engineering·Walter L MurfeeThomas C Skalak
Feb 15, 2005·Cell·Brant M Weinstein
Feb 22, 2005·Current Opinion in Neurobiology·Anne EichmannPeter Carmeliet
Mar 2, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yael HerzogGera Neufeld
Apr 13, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Walter L MurfeeShayn M Peirce
May 17, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Suzanne Claxton, Marcus Fruttiger

❮ Previous
Next ❯

Citations

Jan 1, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Young Goo KimFrederick F Lang
Apr 17, 2013·Pflügers Archiv : European journal of physiology·Ania StefańskaJ J Mullins
May 9, 2012·Medical & Biological Engineering & Computing·Ming Yang, Walter L Murfee
Feb 18, 2011·Journal of Cardiovascular Translational Research·Tiziano TalloneGianni Soldati
Mar 23, 2013·Stem Cells and Development·Alexander BirbrairOsvaldo Delbono
Nov 6, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Peter C StaporWalter L Murfee
Dec 22, 2012·Journal of Vascular Research·Ulrich TiggesWilliam B Stallcup
Jun 23, 2012·BMC Physiology·Molly R Kelly-GossWalter L Murfee
May 31, 2012·Journal of Visualized Experiments : JoVE·Ming YangWalter L Murfee
May 24, 2014·Journal of Vascular Research·Peter C StaporWalter Lee Murfee
Apr 25, 2008·Annals of Plastic Surgery·Shawn A BirchenoughAdam J Katz
Apr 28, 2012·Journal of Vascular Research·Peter C Stapor, Walter L Murfee
Nov 29, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Bruce A CorlissWalter Lee Murfee
Mar 16, 2013·Journal of Comparative Pathology·Y FujiiM Shibutani
Dec 4, 2014·Cell Stem Cell·Rafael KramannBenjamin D Humphreys
Sep 23, 2006·Journal of Cellular and Molecular Medicine·K Norrby
Feb 18, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Marie BillaudBrant E Isakson
Jun 2, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Ming YangWalter L Murfee
Jul 22, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jennifer L RobichauxWalter L Murfee
Mar 25, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Richard S SweatWalter L Murfee
Nov 26, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Molly R Kelly-GossWalter L Murfee
Sep 13, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Parid SavaAnjelica L Gonzalez
Apr 10, 2012·Microvascular Research·Ulrich TiggesRichard Milner
Oct 1, 2011·Microvascular Research·Peter C Stapor, Walter L Murfee
Dec 3, 2016·Pharmacology & Therapeutics·D Sá da BandeiraM Crisan
May 21, 2018·Journal of Vascular Research·Ariana D Suarez-MartinezWalter L Murfee
Sep 5, 2018·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Ariana D Suarez-MartinezWalter L Murfee
May 9, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Laura B PayneJohn C Chappell
Sep 9, 2011·PloS One·Jeroen van den AkkerErik N T P Bakker
Sep 15, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Martin MaibierAxel R Pries
Apr 16, 2019·Journal of Biological Engineering·Huaning Zhao, John C Chappell
May 22, 2020·Molecular & Cellular Proteomics : MCP·Alerie G de la FuenteRobin J M Franklin
May 26, 2017·Cellular & Molecular Biology Letters·Emmanuel AmpofoMatthias W Laschke
May 21, 2017·Scientific Reports·Jessica M MotherwellWalter L Murfee
Jul 10, 2019·Tissue Engineering. Part C, Methods·Jessica M MotherwellWalter L Murfee
Mar 20, 2019·Stem Cells and Development·Simona Delle MonacheVincenzo Mattei
Jun 24, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Luke Maggs, Soldano Ferrone
Jan 31, 2021·Integrative Biology : Quantitative Biosciences From Nano to Macro·Laura Beth PayneJohn C Chappell
Jan 17, 2021·Molecular & Cellular Proteomics : MCP·Alerie G de la FuenteRobin J M Franklin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Related Papers

Methods in Enzymology
Walter L Murfee, Geert W Schmid-Schönbein
The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Jennifer L RobichauxWalter L Murfee
Developmental Dynamics : an Official Publication of the American Association of Anatomists
Ugur OzerdemWilliam Stallcup
© 2022 Meta ULC. All rights reserved