PMID: 9535448Apr 16, 1998Paper

Perivascular delivery of a nitric oxide donor inhibits neointimal hyperplasia in vein grafts implanted in the arterial circulation

The Journal of Thoracic and Cardiovascular Surgery
A ChauxJ M Matloff

Abstract

Nitric oxide has been reported to reduce intimal hyperplasia as a response to arterial injury. This study was designed to assess the possible effect of perivascular application of a nitric oxide donor on neointimal proliferation occurring in veins exposed to the dynamics of the arterial circulation in a hypercholesterolemic rabbit model. Autologous jugular vein grafts were implanted in the carotid circulation of 20 hypercholesterolemic rabbits. A mixture of a biodegradable polymer and the nitric oxide donor, spermine/nitric oxide, which releases nitric oxide with a half-life of 39 minutes, was applied periadventitially at the time of implantation. Controls were veins bathed in saline solution, polymer alone, and polymer plus the carrier vehicle spermine without nitric oxide. Animals (n = 5 in each group) were put to death on day 28 for morphometric analysis, cell count, and immunohistochemical staining. Treatment with perivascular nitric oxide donor significantly decreased wall thickness (126 +/- 24 microm vs 208 +/- 45 microm, p = 0.0017) and area (124 +/- 22 microm2/microm vs 211 +/- 37 microm2/microm, p = 0.005). With the carrier vehicle spermine alone, there was a trend toward reduced intimal thickness, but the change was n...Continue Reading

References

Nov 1, 1991·Hypertension·J T Shepherd, Z S Katusić
Aug 1, 1989·Journal of Vascular Surgery·A ChervuT Henderson
Jan 1, 1985·Circulation Research·A W Clowes, S M Schwartz
Nov 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·A ChauxJ M Matloff
Sep 1, 1995·Circulation Research·S M SchwartzE R O'Brien
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·M J MannV J Dzau
Jun 1, 1996·The International Journal of Biochemistry & Cell Biology·S BardoczP K Lin

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Citations

Sep 23, 2008·Journal of Materials Science. Materials in Medicine·Ajun WanHuili Li
Jun 30, 2011·Cardiovascular Research·Jonathan GolledgeSimon Koblar
Oct 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Sadaf S AhanchiMelina R Kibbe
Jun 22, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Vinit N VaruMelina R Kibbe
Jan 4, 2005·Blood Purification·Prabir Roy-ChaudhurySue C Heffelfinger
Nov 22, 2011·The Journal of Surgical Research·Melissa E HoggMelina R Kibbe
May 11, 2011·Nitric Oxide : Biology and Chemistry·Ashley K VavraMelina R Kibbe
Apr 3, 2007·British Journal of Pharmacology·M R Miller, I L Megson
Oct 8, 2013·Nitric Oxide : Biology and Chemistry·Jing LeiTimothy R Billiar
Sep 21, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·K M Vural, M Bayazit
Jul 27, 2001·The Journal of Surgical Research·G AlbaughJ B Alexander
Jan 8, 2008·Journal of Vascular Surgery·Muneera R KapadiaMelina R Kibbe
Apr 17, 2012·Nitric Oxide : Biology and Chemistry·Matthew J AlefBrian S Zuckerbraun
Aug 8, 2007·Journal of Vascular Surgery·Sadaf S AhanchiMelina R Kibbe
Mar 27, 2012·Current Opinion in Pharmacology·Dominik WiedemannThomas Schachner
Dec 18, 2013·Nitric Oxide : Biology and Chemistry·Monica P RodriguezMelina R Kibbe
Jan 27, 2015·Redox Biology·Rommel C MoralesMelina R Kibbe
Apr 6, 2004·The Annals of Thoracic Surgery·Aurelio Chaux
May 9, 2006·The Journal of Thoracic and Cardiovascular Surgery·Thomas Schachner
May 26, 2009·Expert Opinion on Biological Therapy·Deirdre M O'Connor, Timothy O'Brien
Nov 30, 2007·Free Radical Biology & Medicine·Charles G PearceMelina R Kibbe
Oct 13, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Terutoshi YamaokaYoshihiko Maehara
Jul 11, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Burnett KellyPrabir Roy-Chaudhury
Feb 1, 2005·Journal of Biomedical Materials Research. Part a·Megan C Frost, Mark E Meyerhoff
Feb 23, 2011·Macromolecular Bioscience·M Concepcion SerranoMelina R Kibbe
Mar 23, 2006·The Journal of Vascular Access·P Roy-ChaudhuryB S Kelly
Aug 9, 2005·Cardiology Clinics·Prabir Roy-ChaudhurySue C Heffelfinger

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