Perivascular epithelioid cell tumor (PEComa) of the uterus: an outcome-based clinicopathologic analysis of 41 reported cases

Advances in Anatomic Pathology
Oluwole Fadare

Abstract

The uterus and retroperitoneum have emerged as the most frequently reported anatomic sites of origin of perivascular epithelioid cell tumors (PEComas), a poorly defined neoplasm that is characterized by varying amounts of spindle and epithelioid cells with clear to eosinophilic cytoplasm that display immunoreactivity for melanocytic markers, most frequently HMB-45. Published reports on 41 previously reported uterine PEComas are reviewed in this report. Of these 41 cases, 31 originating in the corpus and for which there was adequate follow-up information (or clinical malignancy) were categorized into 2 groups: (1) a malignant group that was comprised of cases associated with patient death of disease and/or clinical malignancy as evidenced by local and/or distant extension outside of the uterus (n=13, group 1) and (2) a "nonmalignant" group of cases in which neither of the above features were present (n=18, group 2). Groups 1 and 2 did not significantly differ regarding duration of follow-up (25 mo vs. 24.3 mo, respectively, P=0.9) or patient age (45.61 y vs. 43.46 y, respectively, P=0.7). Five of the group 1 patients experienced distant (extra-abdominal) metastases. The group 1 tumors were significantly larger than the group 2 t...Continue Reading

References

Mar 1, 1992·The American Journal of Surgical Pathology·F BonettiG Zamboni
Feb 1, 1991·The American Journal of Surgical Pathology·M PeaC Doglioni
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·R ColombariL Fiore-Donati
Sep 1, 1993·Gynecologic Oncology·F LaffargueA Lachard
Oct 1, 1995·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·K A GyureA W Kennedy
Apr 1, 1995·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·E G SilvaM Morris
Sep 1, 1996·The American Journal of Surgical Pathology·M PeaF Bonetti
Apr 1, 1997·The American Journal of Surgical Pathology·R A PraysonW R Hart
Apr 16, 1998·The Journal of Biological Chemistry·M K JainM E Lee
May 3, 2000·Histopathology·S YamasakiK Suda
Jun 15, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·F BonettiJ K Chan
Jun 15, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·H D TazelaarJ R Srigley
Jan 10, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Esther OlivaRobert H Young
Jan 10, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ann E AndersonRobert H Young
Feb 15, 2002·Pathology International·H YaegashiH Sasano
Mar 16, 2002·Histopathology·L InsabatoJ Rosai
Apr 30, 2002·The American Journal of Surgical Pathology·Dhirendra GovenderAhmed S Essa
May 1, 2002·Journal of Clinical Ultrasound : JCU·Heidi L BraunJohn W Seeds
May 23, 2002·The American Journal of Surgical Pathology·Andrew L FolpeSharon W Weiss
Nov 30, 2002·Trends in Cardiovascular Medicine·Heather C EtcheversNicole M Le Douarin
Feb 4, 2003·Archives of Pathology & Laboratory Medicine·Chin-Chen PanHung Chiang
Feb 8, 2003·International Journal of Surgical Pathology·S S BanerjeeJ Rosai
Feb 8, 2003·International Journal of Surgical Pathology·M Zamecnik, M Michal
Mar 26, 2003·Pathology, Research and Practice·Hiroyuki YanaiKenji Kawabata
Apr 30, 2003·The American Journal of Surgical Pathology·Chin-Chen PanHung Chiang
May 23, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Marit J BootAdriana C Gittenberger-de Groot
Jun 5, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Angel Panizo-SantosFrancisco J Pardo
Aug 2, 2003·Journal of Clinical Pathology·A DimmlerG Faller
Aug 2, 2003·International Journal of Surgical Pathology·Sean K LauDaniel J Luthringer
Sep 10, 2003·The American Journal of Surgical Pathology·Judith Diment, Maurizio Colecchia
Mar 19, 2004·Pathology International·Shiro AdachiSeiji Yamaguchi
Mar 27, 2004·The American Journal of Surgical Pathology·Elvio G SilvaAnais Malpica
Apr 2, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Masaharu Fukunaga
Apr 21, 2004·Pancreas·Glenroy HeywoodJohn H Donohue

❮ Previous
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Citations

Apr 13, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Oluwole Fadare, Sharon X Liang
Mar 8, 2008·International Seminars in Surgical Oncology : ISSO·Oluwole Fadare
Dec 18, 2013·Pathology, Research and Practice·Valentina NatellaLuigi Insabato
Jul 16, 2013·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Cai ZhangChunquan Zhao
May 28, 2014·Seminars in Diagnostic Pathology·Elizabeth Euscher, Anais Malpica
Feb 26, 2014·Gynecologic Oncology Case Reports·Kristen Bunch, Jan Sunde
May 17, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Ying YuHe-Feng Huang
Dec 17, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·H StaleyS Disu
Sep 17, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M A RettenmaierB H Goldstein
Apr 15, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Y PoomtavornA Boonyarangkul
Dec 31, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Esther Oliva
Jul 15, 2009·Journal of Minimally Invasive Gynecology·Nazila ZekryBram H Goldstein
Jul 28, 2016·Journal of Pathology and Translational Medicine·Yoo Jin ChoiHyeyoon Chang
Apr 5, 2014·Pathology International·Haruka OkadaHiroshi Kamma
May 20, 2015·International Journal of Surgery·Angela MusellaVito D'Andrea
May 31, 2017·Journal of Cutaneous Pathology·Lauren N StuartJerad M Gardner
Apr 26, 2012·Rare Tumors·Jonathan S BleekerAndrew L Folpe
Aug 9, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ondrej KovacMartin Cermak
Mar 10, 2015·Journal of Clinical Pathology·Niamh ConlonRajmohan Murali
Feb 25, 2017·Archives of Pathology & Laboratory Medicine·Andres Martin Acosta, Brian P Adley
Jun 20, 2012·International Journal of Surgical Pathology·Catherine C SmithOluwole Fadare
Apr 14, 2016·Molecular and Clinical Oncology·Yin Zhi Lan, Xiao En Hua
Dec 14, 2019·World Journal of Clinical Cases·Alessandra MaranoFelice Borghi
Jun 2, 2012·Cytopathology : Official Journal of the British Society for Clinical Cytology·J L StoneJ Nicklin
Mar 18, 2020·SAGE Open Medical Case Reports·Mariangela GomezRana Naous
Jan 15, 2014·The American Journal of Surgical Pathology·John Kenneth SchoolmeesterMarisa R Nucci
Jan 6, 2016·The American Journal of Dermatopathology·Angel Fernandez-Flores
Apr 7, 2011·Archives of Pathology & Laboratory Medicine·Alireza Zarineh, Jan F Silverman
Aug 14, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yue YuanMeiling Yu

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