Abstract
A perivascular hyaline material (PHyM) was found in gingival biopsies from patients with periodontitis, gingivitis and minimally inflamed gingiva. PHyM was found only in association with the sulcular or pocket epithelium. The extent and frequency of the deposits was quantitatively associated with inflammation of the gingival tissues, as well as with the apical region of periodontal pockets. Evidence for angiogenesis was found in association with the deposition of PHyM. The ultrastructure of the PHyM indicated that the material, which was of an amorphous hyaline appearance at the light microscope level, was composed of multiple basal lamina impregnated with irregular collagen fibrils, fine fibrils and cellular debris. The basal lamina material was degraded at many sites. Immunohistochemistry confirmed the abundance of type IV collagen, supporting the basal lamina origin for PHyM. It is proposed that the deposition of the hyaline matrix is related to the effect of angiogenic and injurious agents on the vascular endothelium. PHyM could contribute to the development of periodontitis by impairing the emigration of polymorphonuclear leukocytes into the gingival sulcus.
References
May 1, 1978·Stain Technology·A Senoo
May 1, 1979·The Histochemical Journal·B L MephamB S Mitchell
Feb 3, 1977·Nature·L J CainciolaC J van Oss
Oct 1, 1977·Nature·P J PolveriniE R Unanue
Jun 1, 1985·Journal of Cutaneous Pathology·K Hashimoto
May 1, 1987·Journal of Periodontal Research·M A Listgarten
Aug 1, 1988·Immunology and Cell Biology·N Hedberg, N Hunter
Jan 1, 1968·Journal of Periodontal Research·H L FreedmanN S Taichman
Jan 1, 1971·Journal of Periodontal Research·J Hock, K Niki
Jan 1, 1983·The Journal of Investigative Dermatology·H Kobayashi, K Hashimoto
May 1, 1984·Journal of Periodontal Research·A C TannerJ M Goodson
Nov 1, 1984·Journal of Periodontal Research·N S TaichmanC C Tsai
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J L GrossD B Rifkin
Jan 1, 1984·Pathology·J P McArdleW H Murphy
Oct 1, 1980·Ultrastructural Pathology·R VrackoW B Carter
Nov 1, 1982·Journal of Clinical Periodontology·J M GoodsonS S Socransky
Aug 27, 1964·Annals of the New York Academy of Sciences·V T MARCHESI
Citations
Jun 1, 1996·The Journal of Pathology·J S PinchbackN Hunter
Feb 7, 2007·Clinical Oral Investigations·Elif Eser SakallioğluGökhan Açikgöz
Jul 15, 2000·Oral Microbiology and Immunology·S R PetersD D Thomas
Feb 1, 1993·Oral Microbiology and Immunology·W L MasseyW R Hume
Apr 1, 1994·Australian Dental Journal·H Zoellner, N Hunter
Nov 4, 2000·Journal of Periodontology·T OyamaM Torii
Mar 18, 2004·Journal of Periodontology·Pelin GüneriHayal Boyacioğlu
Jun 14, 2005·Journal of Periodontology·Jeffrey B BartruffDon L Layman
Apr 24, 2012·Okajimas Folia Anatomica Japonica·Shunji YoshidaIwao Sato
Sep 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L L ShortN Hunter
Oct 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·H Zoellner, N Hunter
Jun 14, 2012·The Journal of Pathology·Manu S DavidHans Zoellner
Nov 28, 2015·Journal of Cutaneous Pathology·Nikolaos KatsoulasAlexandra Sklavounou-Andrikopoulou
May 16, 2012·Journal of Periodontal Research·A KasprzakM Konkol
Apr 26, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mafaz UllahHans Zoellner
Dec 1, 1991·Medical Hypotheses·H Zoellner, N Hunter
Dec 23, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mafaz UllahHans Zoellner
Apr 22, 1999·The Journal of Pathology·C C ChappleN Hunter
Jul 1, 1996·The Journal of Pathology·J S PinchbackN Hunter
Oct 16, 1999·Journal of Dental Research·K W Knox
Jan 26, 2002·Microscopy Research and Technique·Hans ZoellnerNeil Hunter