Perivascular hyaline deposits in inflamed gingival tissues.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Hans Zoellner, N Hunter

Abstract

A perivascular hyaline material (PHyM) was found in gingival biopsies from patients with periodontitis, gingivitis and minimally inflamed gingiva. PHyM was found only in association with the sulcular or pocket epithelium. The extent and frequency of the deposits was quantitatively associated with inflammation of the gingival tissues, as well as with the apical region of periodontal pockets. Evidence for angiogenesis was found in association with the deposition of PHyM. The ultrastructure of the PHyM indicated that the material, which was of an amorphous hyaline appearance at the light microscope level, was composed of multiple basal lamina impregnated with irregular collagen fibrils, fine fibrils and cellular debris. The basal lamina material was degraded at many sites. Immunohistochemistry confirmed the abundance of type IV collagen, supporting the basal lamina origin for PHyM. It is proposed that the deposition of the hyaline matrix is related to the effect of angiogenic and injurious agents on the vascular endothelium. PHyM could contribute to the development of periodontitis by impairing the emigration of polymorphonuclear leukocytes into the gingival sulcus.

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Citations

Jun 1, 1996·The Journal of Pathology·J S PinchbackN Hunter
Jul 15, 2000·Oral Microbiology and Immunology·S R PetersD D Thomas
Feb 1, 1993·Oral Microbiology and Immunology·W L MasseyW R Hume
Apr 1, 1994·Australian Dental Journal·H Zoellner, N Hunter
Sep 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·L L ShortN Hunter
Oct 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·H Zoellner, N Hunter
Nov 28, 2015·Journal of Cutaneous Pathology·Nikolaos KatsoulasAlexandra Sklavounou-Andrikopoulou
Apr 26, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mafaz UllahHans Zoellner
Dec 23, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Mafaz UllahHans Zoellner
Apr 22, 1999·The Journal of Pathology·C C ChappleN Hunter
Oct 16, 1999·Journal of Dental Research·K W Knox

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