Perivascular injury leads to a reduction in vascular reactivity of the collared and to an enhancement on contralateral carotid artery of rats

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Sandra Yasuyo FukadaA M de Oliveira

Abstract

The first response to perivascular injury is observed in the adventitial layer. The purpose of this study was to determine the time course of vascular reactivity alterations after collar injury in rats. We also analyzed the relation between adventitial layer injury and vascular responsiveness to vasoconstrictor agents. Wistar rats had a silicone collar positioned around the carotid artery. The ipsilateral and contralateral arteries were morphologically analyzed 4, 7, 14 and 28 days after injury, and cumulative concentration-response curves to phenylephrine (Phe), angiotensin II (Ang II) and KCl were obtained for arteries isolated from collared and sham-operated groups. Inflammatory cells and fibroblasts were observed in the adventitial layer of collared arteries 4, 7, 14 and 28 days after injury. Intimal thickening was observed in collared arteries only 14 and 28 days after perivascular injury. A decrease in maximum effect values (Emax) for Phe, Ang II and KCl was observed in the collared artery when compared with the contralateral artery at all times after injury, whereas an increase in vascular responsiveness was observed in the contralateral artery 4 days after injury. The impairment of the contractile response preceded the ...Continue Reading

References

Dec 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M M KockxA G Herman
Oct 23, 1990·European Journal of Pharmacology·G R De MeyerA G Herman
Jan 1, 1990·Life Sciences·I WakabayashiM Kurahashi
Jan 1, 1988·Journal of Cardiovascular Pharmacology·P M Vanhoutte
Apr 1, 1987·Atherosclerosis·J HirosumiH Aoki
Dec 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M M KockxA G Herman
Jan 15, 1996·Circulation·Y ShiA Zalewski
Aug 1, 1997·Stroke; a Journal of Cerebral Circulation·K J van EverdingenJ van der Grond
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·G R De MeyerA G Herman
Jun 29, 1999·The Journal of Pharmacy and Pharmacology·Z KerryA Ozer
Mar 24, 2004·British Journal of Pharmacology·D Accorsi-MendonçaA M de Oliveira

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Citations

Jan 23, 2010·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Claudia Roberta de AndradeAna Maria de Oliveira
Apr 23, 2010·Journal of the American Society of Hypertension : JASH·Marie GingrasGérard E Plante
Dec 21, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Claudia Roberta de AndradeAna Maria de Oliveira
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Birgit NeukammJose E Krieger

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