PMID: 42874Oct 1, 1979

Perivascular pH and pial arterial diameter during bicuculline induced seizures in cats

Pflügers Archiv : European journal of physiology
W Kuschinsky, M Wahl

Abstract

The aim of the present study was to correlate locally at the same pial artery the vascular reaction with the perivascular pH during the initial phase of functional hyperemia. As a model of functional hyperemia, bicuculline (3 mg/kg i.v.) induced seizure was taken. Normally, a strong increase of blood pressure occurs together with the start of seizure. Since a discrimination between metabolically induced and pressure dependent vascular reactions is not possible under such conditions, the cats (anesthetized with 40--50 mg/kg chloralose) received in addition 3 mg/kg phentolamine and 10 mg/kg pentobarbital. Under these conditions a significant increase of blood pressure started only 50 s after the onset of seizure. Perivascular pH was recorded using spear type pH microelectrodes in the subarachnoid space surrounding a pial artery. The diameter of the respective artery was measured continuously. After onset of seizure an immediate, increasing perivascular acidosis developed which was accompanied by an increase in pial arterial diameter. The maximal decrease of pH was 0.29 units and occurred 30 s after the start of seizure. These data show that a decrease in perivascular pH can be one factor mediating functional hyperemia in the brain.

References

Jan 1, 1976·Stroke; a Journal of Cerebral Circulation·R R Myers, M Intaglietta
May 1, 1977·Journal of Neurochemistry·A G ChapmanB K Siesjö
Nov 25, 1977·Pflügers Archiv : European journal of physiology·W SchneiderK Thurau
Jul 1, 1978·Physiological Reviews·W Kuschinsky, M Wahl
Dec 15, 1978·Pflügers Archiv : European journal of physiology·R UrbanicsD W Lübbers
Jun 1, 1975·The American Journal of Physiology·R RubioR R CURNISH
Mar 11, 1976·Pflügers Archiv : European journal of physiology·M Wahl, W Kuschinsky
Dec 1, 1974·The American Journal of Physiology·D C HowseF Plum
Jan 1, 1970·Pflügers Archiv : European journal of physiology·M WahlN A Lassen
Mar 1, 1971·Journal of Applied Physiology·D A Herbert, R A Mitchell

Citations

Jun 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·E T Whalley, M Wahl
Sep 1, 1980·Pflügers Archiv : European journal of physiology·J SchraderG W Kreutzberg
Jun 19, 1998·Brain Research·M ChavkoA L Harabin
Nov 1, 1981·Progress in Cardiovascular Diseases·R M BerneR Rubio
Nov 1, 1981·Experimental Neurology·M KiesslingP Kleihues
Dec 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R Sercombe, M Wahl
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H R WinnR M Berne
Jun 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M WahlF Wagner
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P M GrossG M Teasdale
Sep 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Wahl
Oct 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T S ParkR M Berne
Jun 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T L Yaksh, R E Anderson
Jun 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J McCulloch, L Edvinsson
Jun 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E Leniger-Follert
Jun 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I S KanawatiR W Marsh
Jul 1, 1994·Stroke; a Journal of Cerebral Circulation·G L BaumbachD D Heistad
Aug 28, 2019·Circulation Research·Frank M FaraciJohn A Wemmie
Jun 11, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Ákos MenyhártEszter Farkas

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Anion Gap
Arteries
Bicuculline
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beta-Chloralose
Dose-Response Relationship, Drug
Hydrogen-Ion Concentration
Diabutal
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