Periventricular hyperintensity in children with hydrocephalus

Pediatric Radiology
S Hassan A AkbariJoshua S Shimony

Abstract

Magnetic resonance images of children with hydrocephalus often include a rim of hyperintensity in the periventricular white matter (halo). The purpose of this study was to decide between the hypothesis that the halo is caused by cerebrospinal fluid (CSF) flow during the cardiac cycle, and the alternate hypothesis that the halo is caused by anatomical changes (stretching and compression of white matter). Participants were selected from a multicenter imaging study of pediatric hydrocephalus. We compared 19 children with hydrocephalus to a group of 52 controls. We quantified ventricle enlargement using the frontal-occipital horn ratio. We conducted qualitative and quantitative analysis of diffusion tensor imaging in the corpus callosum and posterior limb of the internal capsule. Parameters included the fractional anisotropy (FA), mean diffusivity, axial diffusivity and radial diffusivity. The halo was seen in 16 of the 19 children with hydrocephalus but not in the controls. The corpus callosum of the hydrocephalus group demonstrated FA values that were significantly decreased from those in the control group (P = 4 · 10(-6)), and highly significant increases were seen in the mean diffusivity and radial diffusivity in the hydrocepha...Continue Reading

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Citations

May 21, 2016·Journal of Neurosurgery. Pediatrics·Francesco T ManganoWeihong Yuan
Jun 18, 2016·Trends in Neurosciences·Shinya Ohata, Arturo Alvarez-Buylla
Jul 20, 2019·Journal of Neurosurgery. Pediatrics·Albert M IsaacsDavid D Limbrick
Sep 1, 2018·Journal of Perinatology : Official Journal of the California Perinatal Association·Rebecca A DornerBruno P Soares

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