Periventricular leukomalacia in very low birth weight preterm neonates with high risk for neonatal sepsis

Jornal de pediatria
Rita C SilveiraCristine S da Costa

Abstract

To investigate the association between periventricular leukomalacia (PVL) and neonatal sepsis in very low birth weight infants (VLBWI). We studied VLBWI with a clinical suspicion of infection who had been born at our institution between the 1st of August, 2005 and the 31st of July, 2007. Children were excluded if they died before reaching 14 days, had malformations of the central nervous system or congenital infections. Ultrasound brain scans were carried out on the third day and weekly up until the sixth week of life or discharge. Periventricular leukomalacia was diagnosed by persistent diffuse periventricular hyperechogenecity for more than 7 days, or by periventricular cysts. The VLBWI were separated into two groups on the basis of the presence or absence of PVL. Sepsis was defined as clinical manifestation plus a positive culture. The Mann-Whitney, chi-square and t tests were applied followed by logistic regression. A total of 88 VLBWI were studied. Of these, 62 (70.5%) survived and 51 (57.8%) had PVL. Both groups were similar in terms of birth weight, gestational age, Apgar score, type of delivery, SNAPPE-II score, presence of necrotizing enterocolitis, persistent ductus arteriosus and deaths. Sepsis and mechanical ventila...Continue Reading

Citations

Mar 20, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·B ReschB Pertl
Jan 19, 2013·Journal of Perinatology : Official Journal of the California Perinatal Association·B AlshaikhR Sauve
Oct 28, 2014·Frontiers in Neurology·Jingang LiSuzanne L Miller
Mar 18, 2009·Journal of Child Neurology·Renato S ProcianoyRita C Silveira
Feb 24, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S M RanchhodJ M Dean

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