Periwound dopaminergic sprouting is dependent on numbers of wound macrophages

The European Journal of Neuroscience
P E BatchelorD W Howells

Abstract

Injury to many regions of the central nervous system, including the striatum, results in a periwound or 'abortive' sprouting response. In order to directly evaluate whether macrophages play an important role in stimulating periwound sprouting, osteopetrotic (op/op) mice, which when young are deficient in a variety of macrophage subtypes, were given striatal wounds and the degree of dopaminergic sprouting subsequently assessed. Two weeks postinjury, significantly fewer wound macrophages were present in the striata of op/op mice compared with controls (144 +/- 30.1 in op/op mice vs. 416.6 +/- 82.3 in controls, P < 0.005, analysis performed on a section transecting the middle of the wound). Dopamine transporter immunohistochemistry revealed a marked decrease in the intensity of periwound sprouting in the op/op group of animals. Quantification of this effect using [H3]-mazindol autoradiography confirmed that periwound sprouting was reduced significantly in the op/op mice compared with controls (71.4 +/- 21.7 fmol/mg protein in op/op mice vs. 210.7 +/- 27.1 fmol/mg protein in controls, P < 0.0005). In the two groups of animals the magnitude of the sprouting response in individuals was closely correlated with the number of wound macr...Continue Reading

References

Jan 11, 1976·The Journal of Heredity·S C Marks, P W Lane
Jan 1, 1988·Progress in Brain Research·K S BankiewiczE H Oldfield
Jun 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·O BerezovskayaS Fedoroff
Mar 1, 1995·Journal of Neuroscience Research·G Blevins, S Fedoroff
Nov 8, 1994·The Journal of Comparative Neurology·A N van den Pol, W F Collins
Jan 1, 1993·The Journal of Experimental Medicine·S K BeggI Bertoncello
Jan 24, 1998·Experimental Neurology·M S BeattieW Young
Feb 23, 2000·Experimental Neurology·L D MoonJ W Fawcett
Dec 1, 1954·The Journal of Comparative Neurology·C D CLEMENTE, W F WINDLE
Oct 1, 1956·Physiological Reviews·W F WINDLE
Oct 1, 1950·The Journal of Comparative Neurology·W F WINDLE, W W CHAMBERS
Feb 1, 1951·A.M.A. Archives of Neurology and Psychiatry·W F WINDLE, W W CHAMBERS

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Citations

Sep 2, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Peter E Batchelor, David W Howells
Apr 25, 2006·Journal of Neurotrauma·Theo Hagg, Martin Oudega
Nov 7, 2008·Journal of Neurotrauma·Peter E BatchelorDavid W Howells
Nov 16, 2007·Journal of Neurotrauma·Kumi Nagamoto-CombsColin K Combs
Apr 9, 2008·Brain Research·Peter Egerton BatchelorDavid William Howells
Dec 16, 2006·Brain Research·Claudia RöhlJobst Sievers
Mar 7, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Maria Raffaella BarbaroGiovanni Barbara

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