Perlecan-rich epithelial linings as a background of proliferative potentials of keratocystic odontogenic tumor

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Masayuki TsunekiTakashi Saku

Abstract

The intraepithelial deposit of perlecan, a basement membrane-type heparan sulfate (HS) proteoglycan, has been demonstrated in neoplastic conditions such as salivary gland tumors, odontogenic tumors, and oral carcinoma in situ. Our aim was to determine whether perlecan turnover was enhanced in the lining cells of keratocystic odontogenic tumor (KCOT), which had been recently renamed from odontogenic keratocyst because of its accumulated evidence of neoplasm, as a possible background for neoplastic proliferation. Ten surgical specimens from each of KCOT, dentigerous cyst, and radicular cyst were examined for the expressions of perlecan core protein, HS chains, heparanase, and Ki-67 by immunohistochemistry and in situ hybridization. In KCOT, perlecan core protein and HS chains were localized on the cell border from the parabasal to subkeratinized layers of the lining epithelium. Heparanase was localized in a similar fashion to those for perlecan and HS chains but was within the cytoplasm. mRNA signals for perlecan core protein and heparanase were mostly compatible with their protein signals. Ki-67-positive cells were localized mainly in the second basal cell layers with definitely higher labeling indices (approximately 31.3%, seco...Continue Reading

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Citations

Apr 23, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Chong Huat Siar, Syed Amjad Abbas
Dec 21, 2013·International Journal of Oral Science·Wei-Peng JiangTie-Jun Li
Feb 14, 2012·Pathology, Research and Practice·Masayuki TsunekiTakashi Saku
Nov 26, 2015·Journal of Endodontics·Lisiane BernardiPantelis Varvaki Rados
Jan 5, 2011·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Md Shahidul AhsanTakashi Saku
Nov 10, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Aline Cristina Batista Rodrigues JohannRicardo Alves Mesquita
Apr 10, 2015·Oral and Maxillofacial Surgery·Azadeh Andisheh-Tadbir, Mehrnaz Fakharian
Aug 5, 2014·Oral and Maxillofacial Surgery·Azadeh Andisheh-TadbirPegah Ranjbaran
Jul 29, 2015·Scientific Reports·Masayuki TsunekiHirofumi Arakawa
Dec 25, 2012·Virchows Archiv : an International Journal of Pathology·Masayuki TsunekiTakashi Saku
Aug 11, 2020·Oral Diseases·Marina Gonçalves DinizRicardo Santiago Gomez
Oct 26, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Amol Ramchandra GadbailShailesh Gondivkar
Oct 18, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yukikazu IchimaruBrian G G Oliver
May 1, 2021·Journal of Dental Research, Dental Clinics, Dental Prospects·Mahnaz JabbarzadehNafiseh Vahed
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