Permanent access to the portal system for cellular transplantation using an implantable port device

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Ahmed A DarwishRaymond Reding

Abstract

A novel application of the implantable Port-a-Cath (PAC) system is described in the context of cellular transplantation. A silicone catheter was inserted in a collateral branch of the portal vein and connected to a port device positioned subcutaneously on the left thoracic cage. This permanent vascular access allowed iterative intraportal infusions of allogenic hepatocytes without the need of repeated transhepatic catheterization of the portal vein. Using this technique, repeated infusions of cryopreserved and / or fresh hepatocytes were successfully carried out in 3 children with inborn errors of liver metabolism, with the aim of progressively providing a sufficient mass of transplanted liver cells to stabilize the metabolic condition of the patients. We suggest that this technique might also be valuable in pancreatic islet cell transplantation.

References

May 15, 1998·The New England Journal of Medicine·I J FoxS C Strom
Jul 20, 2001·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·R G BretzelK Federlin
Feb 7, 2002·Lancet·Maurizio MuracaAlberto B Burlina

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Citations

Jun 10, 2006·Journal of Inherited Metabolic Disease·Efienne M Sokal
Apr 9, 2008·Journal of Inherited Metabolic Disease·J Meyburg, G F Hoffmann
Apr 7, 2010·Nature Reviews. Gastroenterology & Hepatology·Anil DhawanRagai R Mitry
May 7, 2009·World Journal of Gastroenterology : WJG·Giada PietrosiBruno Gridelli
Oct 30, 2013·Nature Reviews. Gastroenterology & Hepatology·Benjamin StrueckerIgor M Sauer
Mar 29, 2014·Journal of Inherited Metabolic Disease·Etienne Marc Sokal
Jan 26, 2012·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Piotr HogendorfJanusz Strzelczyk
Jul 31, 2013·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·E ParejaJ Mir
Apr 27, 2010·Medicina clínica·Eugenia ParejaJosé Mir
Jun 1, 2010·Cirugía española·Eugenia ParejaJosé Mir
Jan 19, 2010·Cirugía española·Eugenia ParejaJosé Mir
Jun 17, 2008·Transplantation Proceedings·J MeyburgJ Schmidt
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Xavier StéphenneEtienne M Sokal
Sep 22, 2009·Journal of Internal Medicine·E FitzpatrickA Dhawan
Jan 12, 2008·Pediatric Transplantation·F SmetsE M Sokal
Jul 14, 2012·Journal of Internal Medicine·C JornsB G Ericzon
Mar 13, 2014·Annals of the New York Academy of Sciences·Celine Filippi, Anil Dhawan
Jul 8, 2015·Journal of Thrombosis and Haemostasis : JTH·E M SokalG Mazza
Apr 25, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Charlotte A LeeAnil Dhawan
Jan 10, 2018·World Journal of Transplantation·Ryan D HeathVeysel Tahan
Jul 15, 2015·Korean Journal of Hepato-biliary-pancreatic Surgery·Jae Geun LeeKyung Sik Kim
Mar 31, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Xavier StéphenneEtienne M Sokal
Nov 8, 2014·Current Protocols in Toxicology·Marc C HanselStephen C Strom
Feb 27, 2020·Expert Review of Gastroenterology & Hepatology·Minh Phuong NguyenAnil Dhawan
Aug 2, 2018·Canadian Journal of Gastroenterology & Hepatology·Liana Monteiro da Fonseca CardosoLuiz Anastácio Alves
May 8, 2018·Current Transplantation Reports·James E SquiresAlejandro Soto-Gutierrez
Nov 1, 2008·Expert Review of Endocrinology & Metabolism·Emer FitzpatrickAnil Dhawan
Apr 11, 2021·Journal of Pharmacological and Toxicological Methods·Yevgeniya E KoshmanC Michael Foley
Jul 3, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ronald F ParsonsUNKNOWN ASTS Cellular Transplantation Committee
Aug 21, 2021·Journal of Pharmacological and Toxicological Methods·Yevgeniya E KoshmanC Michael Foley

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