Permanent dynamic transporter-mediated turnover of glutamate across the plasma membrane of presynaptic nerve terminals: arguments in favor and against

Reviews in the Neurosciences
Tatiana Borisova

Abstract

Mechanisms for maintenance of the extracellular level of glutamate in brain tissue and its regulation still remain almost unclear, and criticism of the current paradigm of glutamate transport and homeostasis has recently appeared. The main premise for this study is the existence of a definite and non-negligible concentration of ambient glutamate between the episodes of exocytotic release in our experiments with rat brain nerve terminals (synaptosomes), despite the existence of a very potent Na+-dependent glutamate uptake. Glutamate transporter reversal is considered as the main mechanisms of glutamate release under special conditions of energy deprivation, hypoxia, hypoglycemia, brain trauma, and stroke, underlying an increase in the ambient glutamate concentration and development of excitotoxicity. In the present study, a new vision on transporter-mediated release of glutamate as one of the main mechanisms involved in the maintenance of definite concentration of ambient glutamate under normal energetical status of nerve terminals is forwarded. It has been suggested that glutamate transporters act effectively in outward direction in a non-pathological manner, and this process is thermodynamically synchronized with uptake and pr...Continue Reading

References

Jan 1, 1990·Progress in Neurobiology·M Erecińska, I A Silver
May 1, 1973·The Journal of Cell Biology·B CeccarelliA Mauro
Oct 10, 1970·Nature·K Krnjević
Dec 14, 1971·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J Heuser, R Miledi
Jan 1, 1981·Annual Review of Pharmacology and Toxicology·J C Watkins, R H Evans
Jan 1, 1981·International Review of Neurobiology·A Schousboe
Mar 1, 1994·The Journal of Cell Biology·W J Betz, A W Henkel
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·D JabaudonU Gerber
May 23, 2001·Progress in Neurobiology·N C Danbolt
Sep 8, 2001·Cell and Tissue Research·L NguyenG Moonen
Jun 5, 2003·Nature Neuroscience·David A BakerPeter W Kalivas
Jun 26, 2004·Annual Review of Neuroscience·Thomas C Sudhof
Oct 9, 2004·Progress in Biophysics and Molecular Biology·Pauline CavelierDavid Attwell
Feb 8, 2005·The Journal of Physiology·Pauline Cavelier, David Attwell
Apr 5, 2005·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·T BorisovaN Himmelreich
May 24, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jean-Bernard Manent, Alfonso Represa
Sep 7, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melissa A Herman, Craig E Jahr
Oct 18, 2007·Pharmacology, Biochemistry, and Behavior·Miranda van der ZeydenBen H Westerink
Oct 20, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·David E Featherstone, Scott A Shippy
Jan 1, 1949·The Biochemical Journal·J R STERN, L V EGGLESTON
Jul 21, 2009·The European Journal of Neuroscience·V I CheferT S Shippenberg
Feb 23, 2010·Neurochemistry International·Ludmila Kasatkina, Tatiana Borisova
May 27, 2010·Cellular and Molecular Neurobiology·Tatiana BorisovaNatalia Krisanova
May 14, 2011·British Journal of Pharmacology·Richard J BridgesSarjubhai A Patel
Jan 26, 2012·Frontiers in Systems Neuroscience·Khaled MoussawiPeter W Kalivas
Dec 19, 2012·Annual Review of Physiology·AbdulRasheed A Alabi, Richard W Tsien
Mar 7, 2014·The EMBO Journal·Silvio O Rizzoli

❮ Previous
Next ❯

Citations

Aug 22, 2017·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Bartlomiej SojkaArtur Podhorodecki
Sep 11, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Natalia Pozdnyakova
Jan 27, 2016·Reviews in the Neurosciences·Tatiana Borisova, Arsenii Borysov
Jun 12, 2017·Environmental Science and Pollution Research International·Tatiana BorisovaAlexander P Demchenko
Jan 23, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tatiana BorisovaOlivier Tillement
May 24, 2019·Politics and the Life Sciences : the Journal of the Association for Politics and the Life Sciences·Kathryn NixdorffMalcolm Dando
Apr 1, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·M ObolenskayaT Borisova
Apr 7, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Tatiana BorisovaSergey Andronati

❮ Previous
Next ❯

Methods Mentioned

BETA
biosensor
microsensors

Software Mentioned

eqalign
mathrel

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.