Permanent prostate brachytherapy: Dosimetric results and analysis of a learning curve with a dynamic dose-feedback technique

International Journal of Radiation Oncology, Biology, Physics
Peter AcherRonald Beaney

Abstract

A permanent prostate brachytherapy (PPB) program utilizing intraoperative inverse-planned dynamic dose-feedback was initiated without prior firsthand experience of alternative techniques. The purpose of this study is to assess the dosimetric learning curve associated with this approach. A total of 77 patients underwent PPB implants as monotherapy for localized prostate cancer to a prescription dose of 145 Gy with loose 125I seeds between December 2003 and June 2004. Intraoperative and postoperative dosimetric values, total implanted radioactivity, and operating room (OR) times were compared by sequential case number for all cases. The median intraoperative dosimetric values were: D90 (the minimum dose to 90% of the prostate) = 170 Gy (range, 135-203 Gy), V100 (the volume of the prostate that receives 100% of the prescription dose) = 96% (range, 86-100), V150 = 66% (range, 34-86). Median postoperative dosimetric values were as follows: D90 = 168 Gy (range, 132-197 Gy), V100 = 95% (range, 86-99), V150 = 74% (range, 51-84). Median implanted activity was 0.79 mCi per cubic centimeter of prostate (range, 0.541-1.13). There was no significant correlation by case number on any postoperative dosimetric parameter studied. Door-to-door O...Continue Reading

References

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Citations

Nov 13, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·E Le FurA Valeri
Jan 24, 2012·Brachytherapy·Brian J DavisUNKNOWN American Brachytherapy Society
Feb 23, 2010·International Journal of Radiation Oncology, Biology, Physics·Giuseppina Laura MasucciDaniel Taussky
Feb 4, 2010·Urologic Oncology·Philip VigneriLouis Potters
Jul 25, 2008·Medical Image Analysis·Gabor FichtingerPeter Kazanzides
Dec 18, 2007·Seminars in Radiation Oncology·Daniel E Soto, Patrick W McLaughlin
Nov 13, 2007·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·W FosterE Vigneault
Jan 6, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Nobumichi TanakaYoshihiko Hirao
Jul 1, 2017·Nature Reviews. Urology·Nicholas G ZaorskyEric M Horwitz

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