Permeability factors in nephrotic syndrome and focal segmental glomerulosclerosis

Kidney Research and Clinical Practice
V J SavinM Sharma

Abstract

Circulating permeability factors have been identified in the plasma of patients with focal segmental glomerulosclerosis (FSGS). Post-transplant recurrence of proteinuria, improvement of proteinuria after treatment with plasmapheresis, and induction of proteinuria in experimental animals by plasma fractions each provide evidence for such plasma factors. Advanced proteomic methods have identified candidate molecules in recurrent FSGS. We have proposed cardiotrophin-like cytokine-1 as an active factor in FSGS. Another potential permeability factor in FSGS is soluble urokinase receptor. In our studies, in vitro plasma permeability activity is blocked by substances that may decrease active molecules or block their effects. We have shown that the simple sugar galactose blocks the effect of FSGS serum in vitro and decreases permeability activity when administered to patients. Since the identities of permeability factors and their mechanisms of action are not well defined, treatment of FSGS is empiric. Corticosteroids are the most common agents for initial treatment. Calcineurin inhibitors, such as cyclosporine A, and tacrolimus and immunosuppressive medications, including mycophenylate, induce remission is some patients with steroid-r...Continue Reading

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Citations

Dec 18, 2020·Frontiers in Medicine·Manuel Alfredo Podestà, Claudio Ponticelli
Nov 7, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Dirk J W den BraankerTom Nijenhuis
Apr 29, 2021·Cell and Tissue Research·Fabian BraunTobias B Huber

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Methods Mentioned

BETA
biopsies
biopsy
affinity purification

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