PMID: 3745946Feb 1, 1986Paper

Permeability of abnormal rat skin

The Journal of Investigative Dermatology
R C ScottA W Doss

Abstract

We have measured the permeability (to water in vivo and in vitro) and examined the histology of rat skin after mild, superficial epidermal alterations: scalpel blade (Cat I) and sandpaper abrasion (Cat II), adhesive tape stripping (Cat III), and suction blister top removal (Cat IV). After each alteration the permeability was increased (Cat IV greater than Cat III greater than Cat II greater than Cat I) and the epidermis regenerated in a distinct, biphasic manner, as indicated by the permeability and histology data. The rapid first phase corresponded with a decrease in permeability and the development of a scab (the greater the increased permeability, the slower the rate of regeneration). The second phase was more gradual (with a similar rate of regeneration after each alteration) and corresponded with a return to normal permeability and gradual thickening of the stratum corneum (return to normal corresponded with degree of initial stratum corneum removal). A similar, though slower biphasic regeneration has been reported to occur in human skin following similar types of alterations. It is concluded that abnormal rat skin is suitable for quantifying absorption through abnormal epidermis.

Citations

Aug 26, 2014·Reviews on Environmental Health·Collin M BlattnerHoward I Maibach
Oct 1, 1987·International Journal of Cosmetic Science·M BracherF K Noser
Jan 1, 1989·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·M F JonkmanH J Klasen
Aug 23, 2012·Journal of Applied Toxicology : JAT·Audris ChiangHoward I Maibach
Apr 19, 2005·Archives of Dermatological Research·Jesper B Nielsen
Jun 26, 2002·Photochemistry and Photobiology·Christelle GélisPatricia Vicendo
Jan 10, 1998·Journal of Pharmaceutical Sciences·M WalkerS Winsey

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