Permeability of blood-brain barrier in macaque model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson disease

Synapse
Thibaud ThiollierErwan Bezard

Abstract

Brain bioavailability of drugs developed to address central nervous system diseases is classically documented through cerebrospinal fluid collected in normal animals, i.e., through an approximation as there are fundamental differences between cerebrospinal fluid and tissue contents. The fact that disease might affect brain availability of drugs is almost never considered at this stage although several conditions are associated with blood-brain barrier damage. Building upon our expertise in Parkinson's disease translational research, the present study addressed this gap comparing plasma and cerebrospinal fluid bioavailability of l-3,4-dihydroxyphenylalanine, carbamazepine, quinidine, lovastatin, and simvastatin, in healthy and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated macaques, the gold standard model of Parkinson's disease. The drugs were selected based upon their differential transport across the blood-brain barrier. Interestingly, brain bioavailability of quinidine was decreased while others were unaffected. Pharmacokinetics and pharmacodynamics experiments of drugs addressing Parkinson's disease might thus be performed in healthy animals unless the drugs are known to interact with the organic cation transporter.

References

Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C L MastersK Beyreuther
May 16, 1985·The New England Journal of Medicine·R E PhillipsJ Karbwang
Apr 1, 1983·Biopharmaceutics & Drug Disposition·L N AceR L Kunka
May 1, 1981·Journal of Pharmaceutical Sciences·I J McGilverayC Charette
Jan 1, 1996·European Journal of Clinical Pharmacology·S H SindrupC Broen Christensen
Mar 4, 1998·Neurology·M M Hoehn, M D Yahr
May 12, 2000·British Journal of Pharmacology·M C WalkerP N Patsalos
Apr 25, 2001·British Journal of Clinical Pharmacology·A OwenB K Park
Aug 3, 2001·Nature Reviews. Neuroscience·E BezardC E Gross
Nov 5, 2002·Biopharmaceutics & Drug Disposition·J Cory Kalvass, Tristan S Maurer
Apr 5, 2003·Journal of Neurochemistry·Tiesong ShangCecilia J Hillard
Aug 20, 2003·Archives of Neurology·Liesi E HebertDenis A Evans
Sep 24, 2004·Advanced Drug Delivery Reviews·Danny D ShenKimberly K Adkison
Oct 27, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Angela DoranChenghong Zhang
Oct 30, 2004·Stroke; a Journal of Cerebral Circulation·Pierre AmarencoPierre-Jean Touboul
Jan 25, 2005·Journal of Neural Transmission·C BarciaM-T Herrero
Jan 26, 2005·Annals of Neurology·Rudie KortekaasN Harry Hendrikse
May 26, 2005·Pharmacological Reviews·Brian T Hawkins, Thomas P Davis
Sep 24, 2005·The European Journal of Neuroscience·P M CarveyZ D Ling
Jan 6, 2006·The Journal of Pharmacy and Pharmacology·N S BarakatA A E Ahmed
Jan 18, 2006·Acta Pharmacologica Sinica·Jing-jing SunXiao-dong Liu
Feb 14, 2006·Current Drug Metabolism·Andreas Reichel
Sep 15, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jenny E WestinM Angela Cenci

❮ Previous
Next ❯

Citations

Nov 12, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Franciska ErdőElizabeth de Lange
Sep 15, 2018·Behavioural Pharmacology·Adjia HamadjidaPhilippe Huot
Apr 4, 2019·Frontiers in Neurology·Marie Therese Fuzzati-ArmenteroFabio Blandini
Aug 17, 2019·Frontiers in Aging Neuroscience·Franciska Erdő, Péter Krajcsi
Jul 12, 2021·Advanced Drug Delivery Reviews·Amira Sayed HanafyAlf Lamprecht

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.