PMID: 20629318Jul 16, 2010Paper

Permeability of exogenetic recombine human erythropoietin through placenta barrier to fetal rats with transient uteroplacental ischemia

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Jun ZhouXue-Mei Lin

Abstract

To investigate whether recombine human erythropoietin can cross the placenta barrier in rats with transient uteroplacental ischemia. Rats on day 19 of pregnancy were divided into ischemia-reperfusion group, sham-operated group and rhEPO treated group. Fetal ischemia was induced by bilateral occlusion of the utero-ovarian artery for 20 minutes. 125I-rhEPO or saline were administered intravenously 30 min before the induction of hypoxic-ischemic injury. Fetal rat organs were removed to measure the radioactivity post injury. A small amount of radioactive activity (1.26 +/- 0.28) pg/g was detected in the fetal rats with ischemia-reperfusion. 125I-rhEPO radioactivity increased gradually with time in the placenta, amniotic fluid and fetal tissues of vital organs in the rats of sham-operated group and rhEPO treatment group. There were significant differences in 125I-rhEPO between placental organs and other organs (P < 0.05). The permeability of 125I-rhEPO through the blood brain barrier changed with reperfusion time and peaked about 6 h after reperfusion, and significant differences were found between rhEPO treatment group and sham operation group (P < 0.05). Exogenous rhEPO can cross the placenta barrier and blood-brain barrier and re...Continue Reading

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