PMID: 9184639Jun 1, 1997Paper

Permeability of the blood-brain and blood-spinal cord barriers to interferons

Journal of Neuroimmunology
W PanA J Kastin

Abstract

Interferons (IFNs) are cytokines that produce effects in the CNS even though their production occurs mainly in the periphery. Direct passage of IFNs from blood to CNS could be an important route by which circulating IFNs exert their central effects. In this report, we characterize the pharmacokinetics of the passage of IFNs through the blood-brain and blood-spinal cord barriers in four separate regions: whole brain and the cervical, thoracic and lumbosacral segments of the spinal cord. We found that the spinal cord had greater permeability to IFNs than did the brain. For each corresponding region, the permeability to IFN alpha was higher than that to IFN gamma. Capillary depletion after cardiac perfusion showed that most of the injected IFN was not entrapped by the vasculature but entered the parenchyma of the brain. HPLC showed that most of the IFN gamma entered in intact form. The passage of radioactively labeled IFN gamma into the brain and cervical spinal cord was saturated by a low dose of unlabeled IFN gamma, while passage into the thoracic and lumbosacral spinal cord was not saturated. In contrast, for another cytokine, tumor necrosis factor alpha (TNF alpha), a saturable transport system was present in distal spinal cor...Continue Reading

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Citations

Aug 28, 2004·Brain, Behavior, and Immunity·Martin SchaeferMarkus J Schwarz
Dec 29, 1999·Brain Research·A J KastinW A Banks
Nov 27, 2002·Journal of Affective Disorders·Stefania BonaccorsoMichael Maes
May 14, 1999·Trends in Pharmacological Sciences·M ZoliK Fuxe
Jun 6, 2000·Advanced Drug Delivery Reviews·W Pan, A J Kastin
Apr 28, 1999·Neuroscience Letters·W PanJ M Brennan
Feb 2, 2000·Brain Research Bulletin·N P Turrin, C R Plata-Salamán
Sep 11, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Graciela N Balerio, Modesto C Rubio
Jun 1, 2002·Acta Neuropsychiatrica·M C Wichers, M Maes
Aug 20, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tapas Kumar MakarSuhayl Dhib-Jalbut
Feb 3, 2005·Journal of Neurotrauma·Aileen J AndersonCarl W Cotman
Jun 13, 2012·Brain : a Journal of Neurology·Véronique SchaefferMichel Goedert
May 28, 2013·BioMed Research International·Chung Heon RyuSin-Soo Jeun
Apr 2, 2002·Experimental Neurology·Weihong Pan, Abba J Kastin
Jul 30, 2014·Brain, Behavior, and Immunity·Carolina Hoyo-BecerraDirk M Hermann
Apr 3, 2001·Journal of Neuroimmunology·W Pan, A J Kastin
May 18, 2000·Journal of Neuroimmunology·W PanJ M Brennan
Jan 1, 2003·Journal of Neuroimmunology·Weihong PanAbba J Kastin
Aug 10, 2000·Journal of Veterinary Internal Medicine·A A Webb, G D Muir
Jul 15, 2015·Biological Psychiatry·Nicholas G DowellNeil A Harrison
Aug 25, 2012·Neurotoxicology and Teratology·Paula E Goines, Paul Ashwood
Jun 19, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hung HsuchouAbba J Kastin
Oct 17, 2008·Journal of Comparative Pathology·J BenavidesV Pérez
May 14, 2008·Journal of the Neurological Sciences·Christopher B FordyceDaria A Trojan
Feb 20, 2008·Toxicology Letters·Hiroaki HozumiYutaka Gomita
Apr 4, 2008·Journal of Neurochemistry·Weihong PanAbba J Kastin
Jun 16, 2011·Annals of Neurology·Viktor BartanuszMurat Digicaylioglu
Jan 18, 2006·Experimental Neurology·Weihong PanAbba J Kastin
Sep 2, 2009·Journal of Neurochemistry·Weihong PanAbba J Kastin
Jul 11, 2013·Mediators of Inflammation·Beatrice Mihaela RaduPaolo Francesco Fabene
May 31, 2008·BMB Reports·Yoon Kyung Choi, Kyu-Won Kim
Aug 23, 2011·Brain Research·W Tristram ArscottYang Mao-Draayer
Jan 5, 2000·Experimental Neurology·W PanA J Kastin

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