Permeability of the blood-brain barrier to long-chain alcohols from plasma

Nutrition and Metabolism
R A Gelman, J R Gilbertson

Abstract

Cis-9-octadecenyl alcohol was fed as a dietary supplement to adult male rats for 7 and 14 days. At the end of these feeding intervals, lipids were extracted from brain and liver. The neutral lipids were analyzed for free and esterified long-chain alcohols and alkyl and alk-1-enyl glycerols. Total lipid phosphorus, alkyl acyl and alk-1-enyl acyl phosphoglycerides were determined in the phospholipid fraction. A marked change was observed in these lipid types in the liver, but not in the brain. In liver the free and esterified long-chain alcohols increased threefold following feeding of the dietary supplement. Feeding cis-9-octadecenyl alcohol had no effect on the neutral alkoxy lipids of liver but resulted in an approximately three- to eightfold increase in the ionic alkoxy lipids.

Citations

May 1, 1981·Antimicrobial Agents and Chemotherapy·R D FletcherJ D White
Feb 25, 2009·Ecotoxicology and Environmental Safety·Gauke VeenstraRichard Sedlak
Mar 10, 2015·PloS One·Robin D CouchAli Keshavarzian
Jul 1, 1979·Angewandte Chemie·H K Mangold

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