Permeability of the blood-ocular barrier to mannitol and PAH during experimental diabetes

Current Eye Research
S R Ennis

Abstract

The simultaneous uptake of mannitol, a passive permeability marker, and the organic acid, p-aminohippuric acid, was measured in the anterior and posterior vitreous and retina. Uptake was determined in control, probenecid treated and streptozocin diabetic rats. The unidirectional influx, calculated as a 10 minute PS product for these compounds, was not increased by 2, 4, or 12 weeks of diabetes. A clearance value, calculated using an experimental time of 60 minutes was also examined in order to gauge efflux of these compounds from the eye. The 60 minute clearance value for mannitol in the retina increased approximately 75% in 2, 4, and 12 week diabetic rats. This was an unexpected result due to the lack of increase in the unidirectional flux of mannitol during these same periods of diabetes, and may represent a change in the passive efflux out of the retina. The 60 minute clearance value for mannitol was not significantly changed in either the anterior or posterior vitreous. Experimental diabetes increased the 60 minute clearance value for PAH for the retina by 40% to 70%. In contrast, diabetes did not increase influx of PAH into the anterior or posterior vitreous. Because the unidirectional influx of PAH into the retina was not...Continue Reading

References

Oct 1, 1979·Archives of Ophthalmology·C W JonesM Stein
May 1, 1978·Archives of Ophthalmology·T KrupinB Becker
Mar 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S R EnnisA L Betz
Jan 1, 1989·Documenta Ophthalmologica. Advances in Ophthalmology·J P BootJ A Oosterhuis
Sep 1, 1987·The American Journal of Physiology·H F CserrC S Patlak
Jun 24, 1987·Biochimica Et Biophysica Acta·J B Pritchard
May 1, 1986·Experimental Eye Research·C W JonesO Jonasson
May 1, 1966·The Journal of Physiology·A Ames, F B Nesbett
Jul 1, 1982·Archives of Ophthalmology·C W JonesM M Rusin
Dec 1, 1980·Archives of Ophthalmology·R KleinJ T Ernest
Mar 1, 1984·Acta Pharmacologica Et Toxicologica·M Grabowska-AndénA Magnusson
May 1, 1984·Archives of Ophthalmology·K S MallickR J Anderson
Jul 1, 1984·Archives of Ophthalmology·A K VineW F Howatt
Jun 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J E Cremer, M P Seville
Jul 1, 1983·Archives of Ophthalmology·N P BlairJ G Cunha-Vaz
Jul 1, 1982·Archives of Ophthalmology·A G Palestine, R F Brubaker
Oct 1, 1981·Acta Ophthalmologica·B KrogsaaJ Larsen

❮ Previous
Next ❯

Citations

Aug 30, 2008·NMR in Biomedicine·Bruce A Berkowitz, Robin Roberts

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.