PMID: 8590278Jan 1, 1995Paper

Permeability of the blood-retinal and blood-aqueous barriers in galactose-fed rats

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
L E Caspers-VeluP F Kador

Abstract

Blood-retinal barrier (BRB) and blood-aqueous barrier (BAB) permeability were assessed by various methods to clarify conflicting reports on whether blood-retinal barrier permeability changes occur in diabetic and galactose-fed rats and to assess the potential role of aldose reductase in this process. Different molecular weight probes were utilized in rats fed for 7-11 months either a normal diet or a diet containing 50% galactose with/without the aldose reductase inhibitor AI1576 or Ponalrestat. BRB and BAB were assessed through radiolabelled sucrose permeability studies in eyes where the anterior segment was frozen during dissection compared to eyes where the anterior segments were not frozen and by quantitative autoradiography. In addition, histological studies using Evans Blue dye, microperoxidase and horseradish peroxidase were conducted. In untreated galactose-fed rats a 4-fold increase in the mean permeability surface area product (PA) to sucrose at the BRB was observed when the aqueous humor was not frozen during retinal dissection. However, no increase in the mean PA to sucrose was observed when the aqueous humor of similar eyes was frozen during dissection. Similarly, no retinal vessel permeability increase was observe...Continue Reading

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Citations

Aug 30, 2008·NMR in Biomedicine·Bruce A Berkowitz, Robin Roberts
Jun 27, 2006·Experimental Eye Research·Carol B TorisPeter F Kador
Jan 8, 1999·The Journal of Surgical Research·J L IglesiasR H Turnage
Jul 3, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Antonia M JoussenAnthony P Adamis
Oct 28, 2009·IUBMB Life·Kent LaiKlaas J Wierenga

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