Permeating the blood brain barrier and abrogating the inflammation in stroke: implications for stroke therapy.

Current Pharmaceutical Design
Cesar V BorlonganDavid C Hess

Abstract

Cell therapy has been shown as a potential treatment for stroke and other neurological disorders. Human umbilical cord blood (HUCB) may be a promising source of stem cells for cell therapy. The most desired outcomes occur when stem cells cross the blood brain barrier (BBB) and eventually reach the injured brain site. We propose, from our previous studies, that mannitol is capable of disrupting the BBB, allowing the transplanted cells to enter the brain from the periphery. However, when the BBB is compromised, the inflammatory response from circulation may also be able to penetrate the brain and thus may actually exacerbate the stroke rather than afford therapeutic effects. We discuss how an NF-kB decoy can inhibit the inflammatory responses in the stroke brain thereby reducing the negative effects associated with BBB disruption. In this review, we propose the combination of mannitol-induced BBB permeation and NF-kB decoy for enhancing the therapeutic benefits of cell therapy in stroke.

Citations

Jan 3, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lindsey CrawfordDavid Putnam
Jul 22, 2014·CNS Neuroscience & Therapeutics·Tao YanJieli Chen
Jul 2, 2014·BioMed Research International·Paulo Henrique Rosado-de-CastroLea Mirian Barbosa da Fonseca
May 2, 2016·Brain, Behavior, and Immunity·Grace M NiemiroMichael De Lisio
Jan 20, 2017·CNS Drugs·Mayur M Patel, Bhoomika M Patel
Jul 20, 2016·Journal of Neurotrauma·Whitney S LivingstonLawrence L Latour
Feb 1, 2014·Cell Transplantation·Gabriel S Gonzales-PortilloCesar V Borlongan
Jun 3, 2017·Journal of the American Heart Association·Poornima VenkatJieli Chen
Jul 18, 2019·Expert Opinion on Drug Delivery·Julian P TuazonCesar V Borlongan
May 2, 2020·CNS Neuroscience & Therapeutics·Brooke BonsackCesar V Borlongan
Mar 14, 2017·Frontiers in Cardiovascular Medicine·Adegbenro Omotuyi John Fakoya
Sep 21, 2018·Frontiers in Neurology·Olivera RajkovicEmmanuel Pinteaux
Oct 18, 2019·Brain Circulation·Jack LydenTeng Ma
Nov 4, 2020·Translational Stroke Research·Yinghua JiangXiaoying Wang
Sep 25, 2021·Cell Transplantation·Blaise CozeneCesar V Borlongan

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