PMID: 7014828Jan 1, 1981Paper

Permeation of hairless mouse skin II: membrane sectioning techniques and influence on alkanol permeabilities

Journal of Pharmaceutical Sciences
G L FlynnW I Higuchi

Abstract

The barrier properties of hairless mouse skin were examined by separating the skin into its component epidermal and dermal strata, using both mechanical and thermal techniques, and then assessing the permeability of each stratum to the homologous alkanols. The permeability data, when compared to those obtained previously for full-thickness hairless mouse skin and to new data for the permeability of the alcohols through a perfect lipid membrane, allow assignment of diffusional resistances to the respective, anatomically distinguishable membrane strata. It was found that the principal barrier for the lower alkanols is the epidermis, which contains the stratum corneum. The effective aqueous tissue resistances of the cellular and aqueous strata of full skin, the epidermis, and the dermis were estimated using sectioned skins. This resistance was much greater than that of an equivalent thickness of water. These data and methods represent a novel approach in the permeation analysis of a biological tissue and offer a means of estimating the effects of skin damage on percutaneous absorption.

References

Mar 1, 1964·Archives of Dermatology·A M KLIGMAN, N SHEHADEH

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Citations

Sep 1, 1986·Archives of Environmental Contamination and Toxicology·A S HuqL Condie
Dec 28, 2006·Veterinary Research Communications·P C Mills
Sep 1, 1988·FEMS Microbiology Reviews·R P Jones
Dec 9, 2003·Research in Veterinary Science·P C MillsS E Cross
May 9, 2002·International Journal of Pharmaceutics·Keiko TsutsumiKozo Takayama
Aug 21, 2003·International Journal of Pharmaceutics·Liang FangYasunori Morimoto
Aug 1, 1992·The Journal of Pharmacy and Pharmacology·Y MorimotoH Omiya
Mar 21, 2001·Biological & Pharmaceutical Bulletin·Y TashiroK Itoh
Apr 28, 2004·Drug Development and Industrial Pharmacy·Luciana S FerreiraLucas A M Ferreira
Nov 5, 2014·Cutaneous and Ocular Toxicology·Muhammad HamzaHoward Maibach
Apr 1, 1983·Journal of Pharmaceutical Sciences·C R BehlN F Ho
May 23, 2003·Journal of Pharmaceutical Sciences·Gustavo MerinoRichard H Guy
Aug 3, 2010·International Journal of Pharmaceutics·Liming WangLujia Han
Jul 22, 2015·Pharmaceutical Research·Tomomi HatanakaKenji Sugibayashi
Apr 15, 2004·Australian Veterinary Journal·P C MillsS E Cross
Jul 31, 2003·Journal of Veterinary Pharmacology and Therapeutics·P C MillsS E Cross
Jan 20, 2006·Journal of Veterinary Pharmacology and Therapeutics·P C Mills, S E Cross
May 23, 2006·Drug Discovery Today·I Tuncer Degim
Dec 6, 2005·The Veterinary Journal·P C Mills, S E Cross
Oct 1, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sevgi GüngörRichard H Guy
Jul 21, 2016·Journal of Exposure Science & Environmental Epidemiology·Ji-Eun SeoBae-Hwan Kim
May 26, 2004·International Journal of Pharmaceutics·Satyanarayana ValivetiAudra L Stinchcomb
Sep 1, 1995·Journal of Pharmaceutical Sciences·M E JohnsonR Langer
Jan 10, 2018·Journal of Applied Toxicology : JAT·Yachao CaoHoward Maibach
Feb 5, 2005·American Journal of Veterinary Research·Paul C MillsSheree E Cross
Aug 1, 1985·The Journal of Pharmacy and Pharmacology·K SugibayashiW I Higuchi
Mar 7, 2009·Chemical Reviews·Stefan Balaz
Oct 1, 1993·The Journal of Investigative Dermatology·K AbramsS J Rehfeld
Jan 19, 2019·Journal of Chemical Information and Modeling·Beatrice PecoraroMatthew Traynor

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