Permeation, selectivity and gating in store-operated CRAC channels.

The Journal of Physiology
Beth A McNally, Murali Prakriya

Abstract

Store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels are a widespread mechanism for generating cellular Ca(2+) signals and regulate many Ca(2+)-dependent functions, including transcription, motility and proliferation. The opening of CRAC channels in response to depletion of intracellular Ca(2+) stores involves a cascade of cellular events that culminate in direct interactions between STIM1, the endoplasmic reticulum Ca(2+) sensor, and the channels composed of Orai proteins. Evidence gathered over the last two decades indicates that CRAC channels display a unique functional pore fingerprint characterized by exquisite Ca(2+) selectivity, low unitary conductance, and low permeability to large cations. Here, we review the key pore properties of CRAC channels and discuss recent progress in addressing the molecular foundations of these properties. Structure-function and cysteine-scanning studies have revealed the identity and organization of pore-lining residues, including those that form the selectivity filter, providing a structural framework for understanding CRAC channel pore properties. Recent studies in pore mutants that produce STIM1-independent constitutive channel activation indicate that exquisite Ca(2+) selectivi...Continue Reading

References

Feb 1, 1995·The Journal of General Physiology·A Zweifach, R S Lewis
Jun 1, 1993·The Journal of Physiology·M Hoth, R Penner
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A Zweifach, R S Lewis
Aug 26, 1998·Methods in Enzymology·A Karlin, M H Akabas
Jun 29, 1999·Quarterly Reviews of Biophysics·G Yellen
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·G LoussouarnC G Nichols
Mar 13, 2002·Pflügers Archiv : European journal of physiology·Daniel Bakowski, Anant B Parekh
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Martin D BootmanClaire M Peppiatt
Dec 10, 2002·Annual Review of Physiology·William A Sather, Edwin W McCleskey
Jun 27, 2003·Nature·Atsuo MiyazawaNigel Unwin
Jan 28, 2004·The Journal of General Physiology·Andriy V YerominMichael D Cahalan
Sep 17, 2004·Molecular Membrane Biology·Declan A Doyle
Mar 25, 2005·Physiological Reviews·Anant B Parekh, James W Putney
Jul 12, 2005·Current Biology : CB·Jen LiouTobias Meyer
Sep 1, 2005·The Journal of General Physiology·Xiao-Guang ZhenJian Yang
May 31, 2006·Nature Cell Biology·Christine PeineltJean-Pierre Kinet
Jun 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shenyuan L ZhangMichael D Cahalan
Aug 22, 2006·Nature·Murali PrakriyaPatrick G Hogan
Aug 31, 2006·The Journal of General Physiology·Murali Prakriya, Richard S Lewis
Sep 19, 2006·Current Biology : CB·Monika VigReinhold Penner
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jen LiouTobias Meyer
Aug 19, 2007·The Journal of Biological Chemistry·Zhengzheng LiTao Xu
Nov 17, 2007·The Journal of Physiology·Olivier MignenTrevor J Shuttleworth
Jan 12, 2008·The Journal of Biological Chemistry·Martin MuikChristoph Romanin
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jorge E ContrerasMiguel Holmgren
Apr 19, 2008·The Journal of Biological Chemistry·Shenyuan L ZhangMichael D Cahalan

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Citations

Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Hao DongMichael L Klein
Sep 21, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rajender K MotianiMohamed Trebak
Feb 5, 2014·Nature Communications·Xizhuo WangDonald L Gill
Feb 26, 2014·The Journal of General Physiology·Megumi Yamashita, Murali Prakriya
Oct 12, 2012·Cellular and Molecular Life Sciences : CMLS·Patrick J ShawStefan Feske
May 23, 2012·The Journal of Physiology·Patrick J Shaw, Stefan Feske
Sep 11, 2012·The Journal of Physiology·Trevor J Shuttleworth
Mar 30, 2016·Cell Calcium·Anna B TothMurali Prakriya
Sep 30, 2015·Immunity, Inflammation and Disease·Georgios SogkasJohannes Engelbert Gessner
Nov 12, 2013·Channels·Peter B Stathopulos, Mitsuhiko Ikura
Jun 29, 2013·Channels·Amit Jairaman, Murali Prakriya
Nov 5, 2014·Frontiers in Cell and Developmental Biology·Gerard Apodaca, William J Brown
May 6, 2016·Future Medicinal Chemistry·Chengsen TianMinyong Li
Jun 24, 2016·Molecular Biology of the Cell·Peiyao LiMonika Vig
Sep 30, 2016·Cell Calcium·James P Barger, Patrick F Dillon
Jan 31, 2016·American Journal of Physiology. Cell Physiology·Isabella DerlerChristoph Romanin
Jun 21, 2019·Archives of Insect Biochemistry and Physiology·Surajit De MandalFengliang Jin
Sep 21, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sangyong ChoiZui Pan
Jul 13, 2018·Frontiers in Cell and Developmental Biology·Ingrid CarvachoKhaled Machaca
Aug 5, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amit JairamanMurali Prakriya
Jun 27, 2018·Frontiers in Molecular Neuroscience·Renjitha GopurappillyGaiti Hasan
Mar 25, 2019·European Biophysics Journal : EBJ·Adéla KrizovaIsabella Derler
Aug 8, 2021·International Journal of Molecular Sciences·Adéla Tiffner, Isabella Derler
Jul 30, 2014·The Journal of Physical Chemistry. B·Hao DongGiacomo Fiorin

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