Permeative Amine Introduction for Very Weak Acid Detection in Ion Chromatography

Analytical Chemistry
Hongzhu Liao, Purnendu K Dasgupta

Abstract

A permeative amine introduction device (PAID) is placed after a conventional KOH eluent-suppressed conductometric anion chromatography (SCAC) system. The PAID converts the suppressed eluites from the acid form to the corresponding ammonium salt (NR2H + HX → NR2H2(+) + X(-)) and allows very weak acids HX (pKa ≥ 7.0) that cannot normally be detected by SCAC to be measured by a second conductivity detector following the PAID. Permeative reagent introduction is dilutionless, can be operated without pumps, and provides good mixing (baseline noise 0.8 nS/cm for 27 μM diethylamine) with low band dispersion (as small as 30 μL). Diethylamine (DEA) was chosen as the amine source due to its low pKb value (3.0), high vapor pressure, low toxicity, and low odor. The eluites are thus detected against a low diethylammonium hydroxide (DEAOH) background (5-31 μS/cm) as negative peaks because the equivalent conductance of OH(-) is greater than that of X(-). Reducing the background DEA concentration enhances the detectability of traces of weak acids. Lower background [DEA] will limit the maximum concentration of analyte acids that can be determined; a general concept of peak width measurement at a fixed height is proposed as a solution. Trace impu...Continue Reading

References

Sep 4, 2004·Journal of Biochemical and Biophysical Methods·Yan LiuNebojsa Avdalovic
Mar 28, 2007·Analytica Chimica Acta·Peggy Rimmelin-MauryBernard Quéguiner
Jul 7, 2009·Talanta·Natchanon Amornthammarong, Jia-Zhong Zhang
Oct 14, 2014·Mini Reviews in Medicinal Chemistry·Rajmund Michalski

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Citations

Apr 15, 2016·Analytical Chemistry·Hongzhu LiaoPurnendu K Dasgupta
Mar 1, 2017·Analytical Chemistry·Akinde F KadjoKarsten G Kraiczek
Feb 19, 2021·Analytical Chemistry·Akinde F KadjoKannan Srinivasan
May 28, 2017·Journal of Chromatography. a·C Phillip Shelor, Purnendu K Dasgupta
Feb 15, 2017·Analytical Chemistry·C Phillip ShelorHongzhu Liao

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