PMID: 8592642Sep 29, 1995Paper

Permissive role of corticotropin-releasing factor in the acute stress-induced prolactin release in female rats

Neuroscience Letters
T AkemaJ Toyoda

Abstract

The present study examined the role of corticotropin-releasing factor (CRF) in the acute stress-induced release of prolactin (PRL) in ovariectomized estrogen-primed female rats. Acute immobilization stress induced a marked increase in serum PRL levels in animals treated with saline intraventricularly (i.c.v.). However, a prior icv injection of alpha-helical CRF(9-41), a CRF antagonist, completely eliminated the immobilization-induced PRL release in the majority of animals, providing evidence for involvement of CRF in the acute stress-induced PRL release. On the other hand, an i.c.v. injection of CRF did not affect basal PRL release at any dose in non-stressed animals, suggesting that the peptide plays a permissive role which enables other undefined stress mediator(s) to stimulate PRL release.

References

Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·F BerkenboschR Derijk

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Citations

Mar 4, 2015·Physiology & Behavior·Gwen S StinnettAudrey F Seasholtz
Sep 4, 2007·Neuroscience and Biobehavioral Reviews·Aaron C PawlykFrancis X Brennan
Dec 3, 1999·Journal of Neuroendocrinology·P MeerloJ M Koolhaas
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B BodosiJ M Krueger
Oct 24, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·O Martí, A Armario
Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P MeerloF W Turek

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