Permissive Sense and Antisense Transcription from the 5' and 3' Long Terminal Repeats of Human T-Cell Leukemia Virus Type 1

Journal of Virology
Sylvain LaverdureIsabelle Lemasson

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus, and, as such, its genome becomes chromosomally integrated following infection. The resulting provirus contains identical 5' and 3' peripheral long terminal repeats (LTRs) containing bidirectional promoters. Antisense transcription from the 3' LTR regulates expression of a single gene, hbz, while sense transcription from the 5' LTR controls expression of all other viral genes, including tax. Both the HBZ and Tax proteins are implicated in the development of adult T-cell leukemia (ATL), a T-cell malignancy caused by HTLV-1 infection. However, these proteins appear to harbor opposing molecular functions, indicating that they may act independently and at different time points prior to leukemogenesis. Here, we used bidirectional reporter constructs to test whether transcriptional interference serves as a mechanism that inhibits simultaneous expression of Tax and HBZ. We found that sense transcription did not interfere with antisense transcription from the 3' LTR and vice versa, even with strong transcription emanating from the opposing direction. Therefore, bidirectional transcription across the provirus might not restrict hbz or tax expression. Single-cell analyses reveal...Continue Reading

References

Sep 15, 1989·Biochemical and Biophysical Research Communications·D LaroccaT K Brunck
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R DharG F Vande Woude
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M C OstrowskiG L Hager
Jan 20, 2004·Nature Medicine·Christophe NicotGenoveffa Franchini
Mar 3, 2004·International Journal of Cancer. Journal International Du Cancer·Satoshi TakedaMasao Matsuoka
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yorifumi SatouMasao Matsuoka
Mar 4, 2006·Retrovirology·Marie-Hélène CavanaghBenoit Barbeau
Mar 6, 2007·Journal of Virological Methods·Min Li, Patrick L Green
Mar 27, 2007·Nature Reviews. Cancer·Masao Matsuoka, Kuan-Teh Jeang
Oct 4, 2007·Retrovirology·Sébastien LandryBenoit Barbeau
Feb 5, 2010·Journal of Virology·Mads Heilskov RasmussenFinn Skou Pedersen
Jun 19, 2010·Chemico-biological Interactions·Katerina Chlichlia, Khashayarsha Khazaie
Sep 29, 2011·International Journal of Hematology·Junichiro Yasunaga, Masao Matsuoka
Mar 22, 2012·Nucleic Acids Research·Torsten WurmIsabelle Lemasson
Sep 17, 2013·Virus Research·David SibonEric Wattel
Sep 26, 2013·Current Opinion in Virology·Masao Matsuoka, Jun-ichirou Yasunaga
Oct 5, 2014·The Lancet Oncology·Kenji Ishitsuka, Kazuo Tamura
Feb 24, 2015·Trends in Microbiology·Benoit Barbeau, Jean-Michel Mesnard

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Citations

Nov 18, 2017·Annual Review of Immunology·Charles R M Bangham
Jan 10, 2020·Retrovirology·Masao Matsuoka, Jean-Michel Mesnard
Jun 12, 2018·Frontiers in Microbiology·Mie Kobayashi-IshiharaYasuko Tsunetsugu-Yokota
Jan 16, 2017·Virology Journal·Mamneet MangheraRenée N Douville
Jun 3, 2021·International Journal of Molecular Sciences·Annika P SchnellAndrea K Thoma-Kress
Jun 3, 2021·Vaccines·Zahra GholizadehFabio Romerio

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