Permselectivity in thin membrane nephropathy

The Journal of Clinical Investigation
D M ThomasJ D Williams

Abstract

The glomerular permselectivity to polydisperse neutral dextrans was compared in 6 patients with thin membrane nephropathy (TMN) and 10 healthy controls. Despite having normal renal hemodynamics and minimal proteinuria, the patients with TMN had significantly increased fractional clearance of neutral molecules with Stokes radius > 42 A. Conventional theories of glomerular barrier size selectivity cannot fully explain these data since they would predict that our patients would have had nephrotic range proteinuria.

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Citations

May 10, 2005·Seminars in Nephrology·Martin C Gregory
Dec 25, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Giovanni M FrascàUNKNOWN Italian Renal Immunopathology Group
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Leileata M RussoWayne D Comper
Nov 21, 1998·The Journal of Laboratory and Clinical Medicine·M H HemmelderD de Zeeuw
Aug 10, 2006·Néphrologie & thérapeutique·Jean-Pierre Fauvel, Maurice Laville

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