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Permutation Testing in the Presence of Polygenic Variation

bioRxiv

Jan 29, 2015

Mark Abney

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Abstract

This article discusses problems with and solutions to performing valid permutation tests for quantitative trait loci in the presence of polygenic effects. Although permutation testing is a popular approach for determining statistical significance of a test statistic with an unknown dist...read more

Mentioned in this Paper

Quantitative Trait Loci
Simulation
Population Group
Biochemical Pathway
Polygene
Substance Distribution
Structure
Phenotype Determination
CFC1 gene
Genes
4
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  • Permutation Testing in the Presence of Polygenic Variation

    bioRxiv

    Jan 29, 2015

    Mark Abney

    PMID: 990014571

    DOI: 10.1101/014571

    Abstract

    This article discusses problems with and solutions to performing valid permutation tests for quantitative trait loci in the presence of polygenic effects. Although permutation testing is a popular approach for determining statistical significance of a test statistic with an unknown dist...read more

    Mentioned in this Paper

    Quantitative Trait Loci
    Simulation
    Population Group
    Biochemical Pathway
    Polygene
    4

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