PMID: 8611439Apr 1, 1996Paper

Pernicious anaemia and cancer risk in Denmark

British Journal of Cancer
L MellemkjaerJørgen H Olsen

Abstract

A cohort of 5072 patients with pernicious anaemia was identified in the Danish Hospital Discharge Register from 1977 to 1989 and, through linkage to the Danish Cancer Registry, the occurrence of cancer in the cohort was determined up to 1991. Observed numbers of cancer cases during 1-15 years of follow-up were compared with expected numbers based on national incidence rates. Besides the well-established increased risk for stomach cancer, the analysis also revealed a 2-fold increase in the relative risk for cancer of the buccal cavity and pharynx among pernicious anaemia patients in accordance with previous studies; previously reported elevated risks for other digestive tract cancers were not confirmed. There was a non-significantly increased risk for lymphatic and haematological malignancy but the risk tended to disappear after 5 years of follow-up, indicating a possible selection bias. Decreased risks for cervical cancer and non-melanoma skin cancer were also seen.

Citations

May 3, 2019·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Minkyo SongCharles S Rabkin
Mar 14, 2014·Pancreas·Pari ShahYu-Xiao Yang
Jan 13, 2011·International Journal of Cancer. Journal International Du Cancer·Trine BoysenMads Melbye
Jul 5, 2012·Journal of Gastrointestinal Cancer·Shounak MajumderConstantin A Dasanu
Sep 20, 2018·International Journal of Cancer. Journal International Du Cancer·Paulina Gomez-RubioUNKNOWN PanGenEU Study Investigators
Apr 30, 2002·International Journal of Cancer. Journal International Du Cancer·Alina V BrennerPeter D Inskip
Dec 12, 2012·Alimentary Pharmacology & Therapeutics·L VannellaB Annibale
Jan 24, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Charlene M McShaneLesley A Anderson

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