Pernicious plans revealed: Plasmodium falciparum genome wide expression analysis

Current Opinion in Microbiology
Manuel Llinás, Joseph L DeRisi

Abstract

The asexual intraerythrocytic developmental cycle (IDC) of Plasmodium falciparum is responsible for the majority of the clinical manifestations of malaria in humans. Although malaria has been studied for over a century, the elucidation of the full genome sequence of P. falciparum has now allowed for in-depth studies of gene expression throughout the entire intraerythrocytic stage. As the mainstays of anti-malarial chemotherapy become increasingly ineffective, we need a deeper understanding of fundamental plasmodial bioregulatory mechanisms to successfully subvert them. Recent gene expression studies have begun to examine different aspects of the IDC and are providing key insights into the basic mechanisms of Plasmodium gene regulation and are helping to define gene functions. However, to date, no transcription factor has been fully characterized from Plasmodium and the definitive identification of cis-acting regulatory elements along with their corresponding trans-acting partners is still lacking. The characterization of the transcriptome of P. falciparum is the first major step towards the understanding of the genome wide regulation of gene expression in this parasite. IDC expression data for almost every gene in the P. falcip...Continue Reading

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Citations

Feb 24, 2006·Nucleic Acids Research·Manuel LlinásJoseph L DeRisi
Dec 6, 2005·BMC Biology·Jay R RadkeMichael W White
Mar 25, 2014·Experimental Parasitology·Amit Kumar SubudhiAshis Das
Dec 1, 2012·International Journal for Parasitology. Drugs and Drug Resistance·Philipp LudinPascal Mäser
Jul 28, 2016·Molecular and Biochemical Parasitology·Shiva KumarPradipsinh K Rathod
Sep 8, 2010·International Journal for Parasitology·Denise L Doolan
May 24, 2017·Cold Spring Harbor Perspectives in Medicine·Danny A Milner
May 8, 2021·RNA Biology·Diana Renteria AlvarezKausik Chakrabarti

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