Peromyscus as a Mammalian epigenetic model.

Genetics Research International
Kimberly R ShorterPaul B Vrana

Abstract

Deer mice (Peromyscus) offer an opportunity for studying the effects of natural genetic/epigenetic variation with several advantages over other mammalian models. These advantages include the ability to study natural genetic variation and behaviors not present in other models. Moreover, their life histories in diverse habitats are well studied. Peromyscus resources include genome sequencing in progress, a nascent genetic map, and >90,000 ESTs. Here we review epigenetic studies and relevant areas of research involving Peromyscus models. These include differences in epigenetic control between species and substance effects on behavior. We also present new data on the epigenetic effects of diet on coat-color using a Peromyscus model of agouti overexpression. We suggest that in terms of tying natural genetic variants with environmental effects in producing specific epigenetic effects, Peromyscus models have a great potential.

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Citations

Apr 2, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Amy PerkinsSandra J Kelly
May 3, 2014·Integrative and Comparative Biology·Jessica A Head
Apr 7, 2015·Progress in Biophysics and Molecular Biology·Kimberly R ShorterPaul B Vrana
Jun 5, 2014·Wiley Interdisciplinary Reviews. Developmental Biology·Paul B VranaWallace D Dawson
Jun 24, 2015·Molecular Phylogenetics and Evolution·Sandra LouzadaRaquel Chaves
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Methods Mentioned

BETA
restriction digests
targeted mutations
light microscopy

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