Peroral amphotericin B polymer nanoparticles lead to comparable or superior in vivo antifungal activity to that of intravenous Ambisome® or Fungizone™.

PloS One
J L ItaliaM N V Ravi Kumar

Abstract

Despite advances in the treatment, the morbidity and mortality rate associated with invasive aspergillosis remains unacceptably high (70-90%) in immunocompromised patients. Amphotericin B (AMB), a polyene antibiotic with broad spectrum antifungal activity appears to be a choice of treatment but is available only as an intravenous formulation; development of an oral formulation would be beneficial as well as economical. Poly(lactide-co-glycolode) (PLGA) nanoparticles encapsulating AMB (AMB-NPs) were developed for oral administration. The AMB-NPs were 113 ± 20 nm in size with ~70% entrapment efficiency at 30% AMB w/w of polymer. The in vivo therapeutic efficacy of oral AMB-NPs was evaluated in neutropenic murine models of disseminated and invasive pulmonary aspergillosis. AMB-NPs exhibited comparable or superior efficacy to that of Ambisome® or Fungizone™ administered parenterally indicating potential of NPs as carrier for oral delivery. The present investigation describes an efficient way of producing AMB-NPs with higher AMB pay-load and entrapment efficiency employing DMSO as solvent and ethanol as non-solvent. The developed oral formulation was highly efficacious in murine models of disseminated aspergillosis as well as an inv...Continue Reading

References

Sep 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D W Denning
Jun 6, 2000·Advanced Drug Delivery Reviews·E AllémannR Gurny
Jul 18, 2002·Antimicrobial Agents and Chemotherapy·G DelmasD S Perlin
Mar 5, 2003·International Journal of Pharmaceutics·O KayserS L Croft
Jul 21, 2006·The Journal of Physical Chemistry. B·Jun-Ying XiongTai-Shung Chung
Sep 29, 2006·Antimicrobial Agents and Chemotherapy·Donald C SheppardScott G Filler
Jan 24, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Arlo UptonKieren A Marr
Jan 1, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D NeofytosK Marr
Jan 23, 2009·The Journal of Antimicrobial Chemotherapy·Claudio AnnaloroGiorgio Lambertenghi Deliliers
Jul 15, 2009·Clinical Microbiology Reviews·Taylor R T Dagenais, Nancy P Keller
Aug 14, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Z ErjavecP E Verweij
Dec 30, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jesse C NussbaumThomas S Harrison
Jan 13, 2010·Journal of Tropical Pediatrics·Utpal Kant SinghC P Thakur
Feb 27, 2010·The Lancet Infectious Diseases·Johan van GriensvenMarleen Boelaert
Jul 14, 2010·The Journal of Infection·T LehrnbecherD Schwabe

❮ Previous
Next ❯

Citations

Feb 14, 2013·Therapeutic Delivery·Juan J TorradoIjeoma F Uchegbu
Jul 23, 2013·International Journal of Pharmaceutics·T T H PhamG Barratt
Dec 11, 2014·Therapeutic Delivery·Erica S MuseCristina M Sabliov
Mar 15, 2014·International Journal of Nanomedicine·Tatiana G RibeiroAndré A G Faraco
Apr 27, 2013·The Journal of Antimicrobial Chemotherapy·Alexandre MelkoumovGrégoire Leclair
Jan 2, 2013·Chemical Reviews·Venkat Ratnam DevadasuM N V Ravi Kumar
Jan 17, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hinojal ZazoJosé M Lanao
Jan 15, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Sofia A Costa LimaAnabela Cordeiro-da-Silva
Oct 25, 2013·PloS One·Charitra N GramaGeereddy Bhanuprakash Reddy
Oct 6, 2020·Frontiers in Cellular and Infection Microbiology·Brenda KischkelCarlos P Taborda
Feb 6, 2017·Drug Delivery·Min LiuZhiwen Yang
Aug 10, 2021·International Journal of Pharmaceutics·Biswadip SinhaJan P Möschwitzer

❮ Previous
Next ❯

Methods Mentioned

BETA
dynamic light scattering

Software Mentioned

Minitab

Related Concepts

Related Feeds

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.