PMID: 7726734Feb 1, 1995

Peroxidase-catalysed oxidation of different dibenzazepine derivatives

Archiv der Pharmazie
J F LiégeoisJ Pincemail

Abstract

According to a recent hypothesis suggesting the potential role of free radical formation in the clozapine-induced agranulocytosis, we have evaluated the susceptibility to the peroxidase-mediated oxidation of different dibenzazepine analogues. On the one hand, compounds with an arylamine group such as clozapine or isoclozapine present a high reactivity in the horseradish peroxidase or myeloperoxidase systems and, on the other hand, fluperlapine, though known to induce agranulocytosis, and other dibenzothiazepine and dibenzoxazepine derivatives appear insensitive to oxidation. Consequently, among tricyclic derivatives, the way of diaryloxa- and diarylthiazepine compounds could be an alternative for the development of safer drugs such as antipsychotics.

References

Mar 14, 1991·The New England Journal of Medicine·R J Baldessarini, F R Frankenburg
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Jul 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·P J CoppT G Tennent
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Citations

Sep 23, 1997·Biochemical and Biophysical Research Communications·J F LiégeoisM Lamy
Dec 25, 2010·Journal of Computer-aided Molecular Design·Sébastien Dilly, Jean-François Liégeois
Feb 23, 1999·Fundamental & Clinical Pharmacology·A JegouzoJ C Cazin
Jun 5, 2002·Chemical & Pharmaceutical Bulletin·Toshiyuki KoharaMasafumi Arita
Aug 23, 2006·Expert Opinion on Drug Metabolism & Toxicology·Amit S Kalgutkar, John R Soglia
Mar 8, 2005·Drug Metabolism Reviews·Shufeng ZhouYu-Zong Chen
Feb 22, 2003·CNS Drug Reviews·Bart A Ellenbroek, Jean-François Liégeois

Related Concepts

Catalysis
Dibenzazepines
Oxidation-Reduction
Ovoperoxidase

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