PMID: 7726734Feb 1, 1995

Peroxidase-catalysed oxidation of different dibenzazepine derivatives

Archiv der Pharmazie
J F LiégeoisJ Pincemail


According to a recent hypothesis suggesting the potential role of free radical formation in the clozapine-induced agranulocytosis, we have evaluated the susceptibility to the peroxidase-mediated oxidation of different dibenzazepine analogues. On the one hand, compounds with an arylamine group such as clozapine or isoclozapine present a high reactivity in the horseradish peroxidase or myeloperoxidase systems and, on the other hand, fluperlapine, though known to induce agranulocytosis, and other dibenzothiazepine and dibenzoxazepine derivatives appear insensitive to oxidation. Consequently, among tricyclic derivatives, the way of diaryloxa- and diarylthiazepine compounds could be an alternative for the development of safer drugs such as antipsychotics.


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Jul 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·P J CoppT G Tennent
Sep 1, 1990·Biochemical Pharmacology·J M van ZylB J van der Walt
Jan 1, 1990·Neuroscience and Biobehavioral Reviews·J BruhwylerM Mercier
Aug 1, 1990·The American Journal of Psychiatry·E Haller, R L Binder
Oct 1, 1989·Journal of Medicinal Chemistry·J H RupardH E Smith
Jan 1, 1989·Psychopharmacology·P Krupp, P Barnes
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May 1, 1985·The Journal of Clinical Investigation·B Kalyanaraman, P G Sohnle
Feb 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A GuillouzoP Koch
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Sep 23, 1997·Biochemical and Biophysical Research Communications·J F LiégeoisM Lamy
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