Peroxidases, lactoferrin and lysozyme in peripheral blood neutrophils, gingival crevicular fluid and whole saliva of patients with localized juvenile periodontitis

Oral Diseases
K SuomalainenJ Tenovuo

Abstract

The aim of this study was to examine the longitudinal association of selected non-immune anti-microbial host factors (peroxidases, lysozyme and lactoferrin) to the localized juvenile periodontitis (LJP) disease status. Peroxidases, lysozyme and lactoferrin were quantitated from seven patients with LJP before and after periodontal therapy. Analyses were performed from simultaneously collected samples of peripheral blood polymorphonuclear leukocytes (PMNs), gingival crevicular fluid (GCF from diseased sites) and paraffin-stimulated whole saliva. Similar assays were done also from seven periodontally healthy controls. During untreated phase of LJP myeloperoxidase, lysozyme and lactoferrin concentrations were remarkably elevated in peripheral blood PMNs, also reflected in their high concentrations in GCF. All these values normalised with respect to healthy controls during the periodontal therapy. No similar longitudinal changes were seen in whole saliva but during therapy salivary peroxidase concentrations declined below the control values, in accordance with our previous observations in parotid saliva samples of LJP patients. In LJP the concentrations of lysozyme, lactoferrin and myeloperoxidase are significantly elevated in perip...Continue Reading

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Citations

Jan 12, 2007·Periodontology 2000·Iain L C Chapple, John B Matthews
Feb 1, 1997·Community Dentistry and Oral Epidemiology·J Tenovuo
Jun 6, 2012·Journal of Applied Oral Science : Revista FOB·Daniela de Morais RochaRodrigo Villamarim Soares
Jun 11, 2014·Australian Dental Journal·N YadavP Pahwa
May 5, 2009·Journal of Prosthodontic Research·Daigo YamamotoYoshihiro Terada
Apr 5, 2012·Journal of Periodontal Research·P GlimvallH Jansson
Mar 9, 2021·BioMed Research International·Saber SoltaniAbbas Farahani
Aug 23, 2005·Archives of Biochemistry and Biophysics·Riikka IhalinJorma Tenovuo

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