PMID: 2484656Jan 1, 1989Paper

Peroxidative damage of the erythrocyte membrane in children with nephrotic syndrome

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
F GinevriR Gusmano

Abstract

The structural composition of erythrocyte ghosts was analysed in children affected by steroid-responsive (SRNS) and unresponsive nephrotic syndrome (SUNS). No variation of either intrinsic or extrinsic ghost proteins was found by discontinuous SDS-electrophoresis associated with a very sensitive double staining technique. By contrast, the composition of inner-layer phospholipids--phosphatidyl ethanolamine (PE) and phosphatidyl serine (PS)--was altered in SRNS with minor changes also involving phosphatidic acid, phosphatidyl inositol and lysophosphatidyl choline. Signs of peroxidative damage were present in both SRNS and SUNS ghosts and inside the cells; these included high levels of fluorescent amino-iminopropene derivates of PE and PS, increased intraerythrocytic amounts of malonyldialdehyde and decreased levels of reduced glutathione. Taken together these results support the concept that in SRNS and SUNS erythrocytes are target cells for peroxidative damage. In SRNS peroxidation of membrane lipids results in a marked alteration of the phospholipid composition of erythrocyte ghosts.

References

Apr 13, 1978·The New England Journal of Medicine·B M BrennerH D Humes
Jul 1, 1977·The Journal of Clinical Investigation·M P BohrerW T Willis
Nov 12, 1975·Journal of Chromatography·V E VaskovskyI M Vasendin
Jun 1, 1987·Kidney International·B LelongtY S Kanwar
Jul 26, 1986·Lancet·J M Boulton-JonesL Chandrachud
Aug 9, 1986·British Medical Journal·A SamantaJ Walls
Oct 28, 1988·Journal of Chromatography·G M GhiggeriP G Righetti
Jul 1, 1987·Kidney International·G M GhiggeriC Queirolo
Oct 1, 1987·Kidney International·G M GhiggeriR Gusmano
Jun 1, 1987·Kidney International·J A BertolatusL G Hunsicker
Jul 10, 1986·Biochimica Et Biophysica Acta·C A Dise, D B Goodman
Aug 8, 1985·Biochimica Et Biophysica Acta·J van der ZeeJ van Steveninck
Sep 1, 1985·Kidney International·J A Bertolatus, L G Hunsicker
Jan 1, 1974·Methods in Enzymology·D J Hanahan, J E Ekholm
Jan 1, 1971·British Journal of Haematology·J Stocks, T L Dormandy
Feb 1, 1981·The American Journal of Medicine·B J CarrieB D Myers
Dec 1, 1982·Kidney International·C R BridgesW M Deen
Aug 1, 1983·Kidney International·J J Weening, H G Rennke
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J K DzanduG E Wise
Apr 1, 1984·Kidney International·Y S Kanwar, M L Jakubowski
Mar 1, 1983·Kidney International·P OzanneH J Meiselman
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

❮ Previous
Next ❯

Citations

Mar 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·G CandianoR Gusmano
Mar 1, 1991·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·S TúriE Dobos
Aug 1, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ashraf BakrRasha Hassan
Jan 1, 1997·Free Radical Biology & Medicine·E PeuchantC Combe
Jan 12, 2000·Archives of Disease in Childhood·S KinraB C Kabi
Jan 1, 1994·Kidney International·I IchikawaT Yoshioka
Jul 19, 2011·Clinical and Experimental Immunology·R BertelliG M Ghiggeri
Apr 27, 2013·Biochimica Et Biophysica Acta·Maurizio BruschiGian Marco Ghiggeri
Sep 5, 2006·Biochemical and Biophysical Research Communications·Luca MusanteGian Marco Ghiggeri
Feb 9, 2007·Journal of the American Society of Nephrology : JASN·Luca MusanteGian Marco Ghiggeri
Sep 17, 2014·Paediatrics and International Child Health·Malcolm G Coulthard
Dec 28, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Maurizio BruschiGian Marco Ghiggeri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.