Peroxin 5: a cycling receptor for protein translocation into peroxisomes

The International Journal of Biochemistry & Cell Biology
Chris P Williams, Will A Stanley

Abstract

Peroxins are proteins that regulate the biogenesis of peroxisomes-small vesicular subcellular organelles essential for human life and health. A key peroxin - to date the best studied - is peroxin 5. Structurally, peroxin 5 is a bi-domain protein of about 70 kDa containing both globular and non-globular segments and displaying conformational flexibility. Functionally, it is a cycling receptor for importing essential enzymes into the peroxisome lumen, facilitated by highly promiscuous interactions with numerous proteins and possibly lipids. Peroxin 5 has medical significance in that (i) congenital defects can lead to fatal peroxisome biogenesis disorders, (ii) inefficient peroxisome targeting is linked to disease and aging and (iii) differences between human peroxin 5 and homologues in pathogens may be exploited in the development of therapeutics.

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Citations

May 3, 2012·Proceedings of the National Academy of Sciences of the United States of America·John R BankstonWilliam N Zagotta
Mar 5, 2011·Molecular Biology of the Cell·Oksana IvashchenkoMarc Fransen
Dec 26, 2012·Biochemical and Biophysical Research Communications·Melisa Gualdrón-López, Paul A M Michels
Apr 20, 2014·Biochimica Et Biophysica Acta·Chris Williams
Sep 22, 2017·Cell Cycle·Wei Wang, Suresh Subramani
Feb 6, 2018·Acta Crystallographica. Section F, Structural Biology Communications·Ameena M AliMatthew R Groves

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