Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
E El Eter, A A Al-Masri

Abstract

The production of oxygen free radicals in type 2 diabetes mellitus contributes to the development of complications, especially the cardiovascular-related ones. Peroxiredoxins (PRDXs) are antioxidant enzymes that combat oxidative stress. The aim of this study was to investigate the associations between the levels of PRDX isoforms (1, 2, 4, and 6) and cardiovascular risk factors in type 2 diabetes mellitus. Fifty-three patients with type 2 diabetes mellitus (28F/25M) and 25 healthy control subjects (7F/18M) were enrolled. We measured the plasma levels of each PRDX isoform and analyzed their correlations with cardiovascular risk factors. The plasma PRDX1, -2, -4, and -6 levels were higher in the diabetic patients than in the healthy control subjects. PRDX2 and -6 levels were negatively correlated with diastolic blood pressure, fasting blood sugar, and hemoglobin A1c. In contrast, PRDX1 levels were positively correlated with low-density lipoprotein and C-reactive protein levels. PRDX4 levels were negatively correlated with triglycerides. In conclusion, PRDX1, -2, -4, and -6 showed differential correlations with a variety of traditional cardiovascular risk factors. These results should encourage further research into the crosstalk b...Continue Reading

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Citations

Nov 24, 2017·Frontiers in Pharmacology·Stefania SchiavoneLuigia Trabace
May 8, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Polash Chandra KarmakarBuom-Yong Ryu
Nov 8, 2017·Journal of Inherited Metabolic Disease·Markus Hecker, Andreas H Wagner
May 16, 2019·Oxidative Medicine and Cellular Longevity·Konstantina P PoulianitiChristina Karatzaferi
Jan 16, 2021·Biomedical Chromatography : BMC·Divya NairSudarslal Sadasivan Nair

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Abfrontier
SPSS

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