Peroxiredoxins and Beyond; Redox Systems Regulating Lung Physiology and Disease.

Antioxidants & Redox Signaling
Evan A ElkoYvonne M W Janssen-Heininger

Abstract

Significance: The lung is a unique organ, as it is constantly exposed to air, and thus it requires a robust antioxidant defense system to prevent the potential damage from exposure to an array of environmental insults, including oxidants. The peroxiredoxin (PRDX) family plays an important role in scavenging peroxides and is critical to the cellular antioxidant defense system. Recent Advances: Exciting discoveries have been made to highlight the key features of PRDXs that regulate the redox tone. PRDXs do not act in isolation as they require the thioredoxin/thioredoxin reductase/NADPH, sulfiredoxin (SRXN1) redox system, and in some cases glutaredoxin/glutathione, for their reduction. Furthermore, the chaperone function of PRDXs, controlled by the oxidation state, demonstrates the versatility in redox regulation and control of cellular biology exerted by this class of proteins. Critical Issues: Despite the long-known observations that redox perturbations accompany a number of pulmonary diseases, surprisingly little is known about the role of PRDXs in the etiology of these diseases. In this perspective, we review the studies that have been conducted thus far to address the roles of PRDXs in lung disease, or experimental models use...Continue Reading

References

Feb 1, 1989·The American Review of Respiratory Disease·A M CantinR G Crystal
Jun 1, 1987·The Journal of Clinical Investigation·A M CantinR G Crystal
Dec 14, 1969·Journal of Molecular Biology·J R Harris
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·H Z ChaeS G Rhee
Oct 6, 1997·American Journal of Respiratory Cell and Molecular Biology·N HagimotoN Hara
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·P MontuschiP J Barnes
Dec 31, 1998·American Journal of Respiratory Cell and Molecular Biology·K KuwanoN Hara
Jul 7, 1999·The Journal of Clinical Investigation·K KuwanoN Hara
Mar 25, 2000·Journal of Biochemistry·A Okado-MatsumotoN Taniguchi
May 15, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·H S KimL B Clerch
Nov 22, 2001·Biochemical and Biophysical Research Communications·J W ChangY J Yoo
Feb 22, 2002·The Journal of Pathology·Vuokko L KinnulaY Soini
Mar 28, 2002·The Journal of Biological Chemistry·Seung-Rock LeeSue Goo Rhee
Apr 24, 2002·Biochemistry·Zachary A WoodP Andrew Karplus
Nov 20, 2002·Cell·Agnès DelaunayMichel B Toledano
Apr 26, 2003·Science·Zachary A WoodP Andrew Karplus
Sep 23, 2003·American Journal of Respiratory Cell and Molecular Biology·Chung-Wai ChowGregory P Downey
Mar 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Y ManevichA B Fisher
Mar 30, 2004·Journal of Molecular Biology·Christine EvrardJean-Paul Declercq
May 12, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yan WangAron B Fisher
Jun 23, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hye-Youn ChoSteven R Kleeberger
Jul 9, 2004·International Journal of Cancer. Journal International Du Cancer·Siri T LehtonenVuokko L Kinnula
Nov 6, 2004·Free Radical Biology & Medicine·Yan WangAron B Fisher
Dec 14, 2004·The Journal of Biological Chemistry·Hyun Ae WooSue Goo Rhee
May 7, 2005·FEBS Letters·Jong Wook ChangYung Joon Yoo
May 17, 2005·American Journal of Respiratory and Critical Care Medicine·Vuokko L KinnulaTim D Oury
Jan 10, 2006·American Journal of Respiratory Cell and Molecular Biology·Yan WangAron B Fisher
Feb 21, 2006·Antioxidants & Redox Signaling·Yan WangAron B Fisher

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Citations

Nov 7, 2019·American Journal of Physiology. Cell Physiology·Shi B ChiaYvonne M W Janssen-Heininger
Jan 1, 2020·BMC Pulmonary Medicine·Tetsuya HanakaHiroshi Mukae
Dec 21, 2020·Redox Biology·Haya AlshaabiBrian Cunniff
Mar 20, 2021·Frontiers in Oncology·Pierre Montay-GruelCharles L Limoli
Aug 14, 2019·Current Opinion in Physiology·Zdravka DanevaSwapnil K Sonkusare
Jul 1, 2020·Free Radical Biology & Medicine·Helmut Sies, Michael J Parnham
Jul 19, 2021·Basic Research in Cardiology·Ioanna AndreadouRainer Schulz
Jul 11, 2020·Cancer Cell·John D HayesKenneth D Tew

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Methods Mentioned

BETA
nuclear translocation
protein folding
RNA-seq
xenograft
xenoplants
electrophoresis
transgenic

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