Peroxiredoxins and the Regulation of Cell Death

Molecules and Cells
Mark B Hampton, Karina M O'Connor

Abstract

Cell death pathways such as apoptosis can be activated in response to oxidative stress, enabling the disposal of damaged cells. In contrast, controlled intracellular redox events are proposed to be a significant event during apoptosis signaling, regardless of the initiating stimulus. In this scenario oxidants act as second messengers, mediating the post-translational modification of specific regulatory proteins. The exact mechanism of this signaling is unclear, but increased understanding offers the potential to promote or inhibit apoptosis through modulating the redox environment of cells. Peroxiredoxins are thiol peroxidases that remove hydroperoxides, and are also emerging as important players in cellular redox signaling. This review discusses the potential role of peroxiredoxins in the regulation of apoptosis, and also their ability to act as biomarkers of redox changes during the initiation and progression of cell death.

References

Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·V GoossensW Fiers
Dec 9, 1997·Cell·G S Salvesen, V M Dixit
Sep 12, 1998·Science·J M Adams, S Cory
Jul 6, 2000·FEBS Letters·T Finkel
Mar 27, 2001·Biochemical and Biophysical Research Communications·M J Burkitt, P Wardman
Apr 4, 2001·The Journal of Biological Chemistry·S F ShihJ Y Lin
Feb 22, 2002·The Journal of Pathology·Vuokko L KinnulaY Soini
Feb 28, 2002·Molecular Cell·Tzu-Ching MengNicholas K Tonks
Apr 24, 2002·Biochemistry·Zachary A WoodP Andrew Karplus
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Diane R WonseyChi V Dang
Jun 14, 2002·FEBS Letters·Mark B HamptonChristine C Winterbourn
Nov 20, 2002·Cell·Agnès DelaunayMichel B Toledano
Jan 9, 2003·Trends in Biochemical Sciences·Zachary A WoodLeslie B Poole
Apr 26, 2003·Science·Zachary A WoodP Andrew Karplus
Jul 4, 2003·The EMBO Journal·Makio HayakawaKiyomi Kikugawa
Jul 29, 2004·The Journal of Biological Chemistry·Tong-Shin ChangSue Goo Rhee
Jun 24, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M D'AlessioL Ghibelli
Jan 13, 2006·Nature Chemical Biology·Alexei DegterevJunying Yuan
Jan 13, 2006·Nature Chemical Biology·Valerian E KaganGregory G Borisenko
Mar 17, 2006·Free Radical Biology & Medicine·Marcelo G BoniniRonald P Mason
Apr 26, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Joo Hun ParkSung Chul Hwang
Oct 25, 2006·The Journal of Cell Biology·Sudit S MukhopadhyaySharon E Plon
Feb 24, 2007·Biochemical and Biophysical Research Communications·Lianqin LiMasuo Obinata
Mar 3, 2007·The Journal of Biological Chemistry·Alexander V PeskinChristine C Winterbourn
Jan 1, 2008·Free Radical Biology & Medicine·Andrew G CoxMark B Hampton
Apr 19, 2008·Nature Chemical Biology·Christine C Winterbourn
May 27, 2008·Free Radical Biology & Medicine·Kristin K BrownMark B Hampton
Jun 12, 2008·Free Radical Biology & Medicine·Christine C Winterbourn, Mark B Hampton
May 26, 2009·Biochemistry·Andrew G CoxMark B Hampton
Dec 23, 2009·The Biochemical Journal·Andrew G CoxMark B Hampton
Apr 8, 2011·Journal of the American Society for Mass Spectrometry·Jenna ScotcherPat R R Langridge-Smith
Mar 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Cecilia Garcia-PerezGyörgy Hajnóczky
Apr 10, 2012·Nature Chemical Biology·Chuan-Xu LiuGuo-Qiang Chen
Aug 21, 2012·Free Radical Biology & Medicine·Reagan M JarvisElizabeth C Ledgerwood
Apr 9, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xin-yan WangXiu-qin Li

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Citations

Feb 3, 2016·Molecules and Cells·Sue Goo Rhee
Sep 16, 2016·Journal of Biomolecular Structure & Dynamics·Vida Jafari AzadMojtaba Falahati
Dec 15, 2017·Antioxidants & Redox Signaling·Mark B HamptonCarola A Neumann
Dec 1, 2017·Antioxidants & Redox Signaling·Stephen Jun Fei ChongShazib Pervaiz
Sep 15, 2018·Journal of Neurochemistry·D Allan Butterfield, Debra Boyd-Kimball
Aug 28, 2017·Tissue Engineering and Regenerative Medicine·Jun Hee LeeSang-Mo Kwon
Jul 9, 2020·Cell Biology International·Mi Hye KimDong-Seok Lee
Nov 18, 2018·Nature Reviews. Gastroenterology & Hepatology·Eric L Campbell, Sean P Colgan
Aug 23, 2018·Molecular Biology of the Cell·Yumi Uetake, Greenfield Sluder
Jun 12, 2017·Biochemistry. Biokhimii︠a︡·N K ZenkovE B Menshchikova
Nov 30, 2020·Free Radical Biology & Medicine·Eloisa Aparecida Vilas-BoasLeticia Prates Roma

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Methods Mentioned

BETA
transgenic

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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