Peroxiredoxins: hidden players in the antioxidant defence of human spermatozoa

Basic and Clinical Andrology
Cristian O'Flaherty

Abstract

Spermatozoon is a cell with a precious message to deliver: the paternal DNA. Its motility machinery must be working perfectly and it should be able to acquire fertilizing ability in order to accomplish this mission. Infertility touches 1 in 6 couples worldwide and in half of the cases the causes can be traced to men. A variety of conditions such as infections of the male genital tract, varicocele, drugs, environmental factors, diseases, smoking, etc., are associated with male infertility and a common feature among them is the oxidative stress in semen that occurs when reactive oxygen species (ROS) are produced at high levels and/or when the antioxidant systems are decreased in the seminal plasma and/or spermatozoa. ROS-dependent damage targets proteins, lipids, and DNA, thus compromising sperm function and survival. Elevated ROS in spermatozoa are associated with DNA damage and decreased motility. Paradoxically, ROS, at very low levels, regulate sperm activation for fertilization. Therefore, the regulation of redox signaling in the male reproductive tract is essential for fertility. Peroxiredoxins (PRDXs) play a central role in redox signaling being both antioxidant enzymes and modulators of ROS action and are essential for pat...Continue Reading

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Citations

Sep 8, 2017·International Journal of Molecular Sciences·Do-Yeal RyuMyung-Geol Pang
Oct 13, 2017·Biology of Reproduction·Cristian O'Flaherty, David Matsushita-Fournier
Nov 12, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Tania Morielli, Cristian O'Flaherty
Jan 1, 2020·Antioxidants & Redox Signaling·Eleonora Scarlata, Cristian O'Flaherty
Apr 24, 2020·Andrologia·Cayde Ritchie, Edmund Y Ko
Feb 26, 2020·Antioxidants·Pei You WuCristian O'Flaherty
May 6, 2020·International Journal of Molecular Sciences·Manesh Kumar Panner SelvamAshok Agarwal
Nov 28, 2018·Antioxidants·Cristian O'Flaherty
Nov 23, 2019·Antioxidants·Fernando J PeñaCristina Ortega Ferrusola
Jun 24, 2021·Scientific Reports·Seyed-Morteza Javadirad, Mohammad Mokhtari
Aug 28, 2021·Antioxidants·Zofia E MadejaNatalia Rozwadowska
Oct 30, 2021·Antioxidants & Redox Signaling·Steven Serafini, Cristian O'Flaherty

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