Peroxisomal lipid degradation via beta- and alpha-oxidation in mammals

Cell Biochemistry and Biophysics
G P MannaertsM Casteels

Abstract

Peroxisomal beta-oxidation is involved in the degradation of long chain and very long chain fatty acyl-(coenzyme A)CoAs, long chain dicarboxylyl-CoAs, the CoA esters of eicosanoids, 2-methyl-branched fatty acyl-CoAs (e.g. pristanoyl-CoA), and the CoA esters of the bile acid intermediates di- and trihydroxycoprostanic acids (side chain of cholesterol). In the rat, straight chain acyl-CoAs (including the CoA esters of dicarboxylic fatty acids and eicosanoids) are beta-oxidized via palmitoyl-CoA oxidase, multifunctional protein-1 (which displays 2-enoyl-CoA hydratase and L-3-hydroxyacyl-CoA dehydrogenase activities) and peroxisomal thiolase. 2-Methyl-branched acyl-CoAs are degraded via pristanoyl-CoA oxidase, multifunctional protein-2 (MFP-2) (which displays 2-enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase activities) and sterol carrier protein-X (SCPX; displaying 2-methyl-3-oxoacyl-CoA thiolase activity). The side chain of the bile acid intermediates is shortened via one cycle of beta-oxidation catalyzed by trihydroxycoprostanoyl-CoA oxidase, MFP-2 and SCPX. In the human, straight chain acyl-CoAs are oxidized via palmitoyl-CoA oxidase, multifunctional protein-1, and peroxisomal thiolase, as is the case in the rat. The ...Continue Reading

Citations

Dec 21, 2006·Histochemistry and Cell Biology·Werner J KovacsSkaidrite K Krisans
Sep 29, 2011·Modern Rheumatology·Savas GuzelVedat Hamuryudan
Oct 10, 2001·Progress in Lipid Research·N M Verhoeven, C Jakobs
Apr 16, 2003·European Journal of Biochemistry·Minne CasteelsPaul P Van Veldhoven
Apr 24, 2009·Seminars in Liver Disease·Wing-Kin SynAnna Mae Diehl
May 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Alberto DávalosCarlos Fernández-Hernando
Apr 29, 2004·SAR and QSAR in Environmental Research·S DimitrovO Mekenyan
Oct 26, 2010·Antioxidants & Redox Signaling·Roberto GambinoMaurizio Cassader
Dec 24, 2010·Current Opinion in Lipidology·Carlos Fernández-HernandoKathryn J Moore
Jan 1, 2009·BMJ Case Reports·Sofie J HuybrechtsDavid Cassiman
May 10, 2011·Annual Review of Nutrition·Kathryn J MooreCarlos Fernández-Hernando
Mar 20, 2010·Mediators of Inflammation·Elizabeth HijonaLuis Bujanda
Jul 16, 2004·The Journal of Clinical Investigation·Jeffrey D Browning, Jay D Horton
Mar 23, 2004·Environmental Health Perspectives·Valerie A BakerJohn C Rockett
Jan 27, 2004·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K UmeharaG Miyamoto
Jan 19, 2016·Biochimica Et Biophysica Acta·Wilhelm W Just, Johan Peränen
Feb 3, 2011·Journal of Molecular and Cellular Cardiology·Martin StěrbaVladimír Geršl
Dec 9, 2008·Biotechnology and Bioengineering·Amol V JanorkarMartin L Yarmush
May 11, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Angela CintolesiRamon Gonzalez
Sep 14, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Sonal DesaiLixin Zhu
Feb 17, 2005·Journal of Molecular Biology·Marc FransenPaul P Van Veldhoven
Dec 7, 2005·Journal of Molecular Biology·Jukka P TaskinenRik K Wierenga
Oct 24, 2002·Archives of Biochemistry and Biophysics·Yi Shan LuoThierry Chardot
Jan 6, 2017·Scientific Reports·Sonia R SalvatoreFrancisco J Schopfer
Nov 27, 2014·Journal of Lipid Research·Nathaniel W SnyderIan A Blair
Aug 19, 2003·Journal of Lipid Research·Veerle FoulonPaul P Van Veldhoven
May 18, 2004·Journal of Lipid Research·Que Lan, Randall J Massey
Feb 8, 2018·Frontiers in Molecular Neuroscience·Timothy J TraceyShyuan T Ngo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biosynthetic Transformations

Biosyntheic transformtions are multi-step, enzyme-catalyzed processes where substrates are converted into more complex products in living organisms. Simple compounds are modified, converted into other compounds, or joined together to form macromolecules. Discover the latest research on biosynthetic transformations here.